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Reprogrammed Differentially Methylated Regions   (All Phenotype and Disease Associations tracks)

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Data last updated at UCSC: 2010-07-23

Description

This track provides the location of genomic regions that show differential DNA methylation (DNAm) between induced pluripotent stem (iPS) cells and their parental fibroblasts. M values represent averaged methylation values across all samples in a given cell type. R-DMRs were identified using Comprehensive High-Throughput Arrays for Relative Methylation (CHARM) analysis. For a detailed description of CHARM analysis, please see Irizarry RA et al., 2008.

Credits

Thanks to Andrew P. Feinberg and Christine Ladd-Acosta for providing this annotation data.

References

Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J, Schlaeger T, Daley GQ, Feinberg AP. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature Genetics 2009 Dec;41(12):1350-1353.

Irizarry RA, Ladd-Acosta C, Carvalho B, Wu H, Brandenburg SA, Jeddeloh JA, Wen B, Feinberg AP. Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Research 2008 May;18(5):780-90.