Description
The miRNA track shows microRNAs from
miRBase.
Display Conventions and Configuration
The precursor forms of
microRNAs (mirs) are represented by thin blocks. miRNAs in the sense
orientation are shown in black; those in the reverse orientation are colored
grey.
To display only those items
that exceed a specific unnormalized score, enter a minimum score between 0 and
1000 in the text box at the top of the track description page.
Methods
Precursor miRNAs from
miRBase
were aligned against the genome
using blat. The extents of the precursor sequences were not generally known,
and were predicted based on base-paired hairpin structure. miRBase is described
in Griffiths-Jones, S. et al. (2006). The miRNA Registry is described in
Griffiths-Jones, S. (2004) and Weber, M.J. (2005) in the References section
below.
Credits
This track was created by Michel Weber of
Laboratoire de Biologie Moléculaire Eucaryote,
CNRS Université Paul Sabatier
(Toulouse, France), Yves Quentin of Laboratoire de Microbiologie et Génétique
Moléculaires (Toulouse, France) and Sam Griffiths-Jones of
The Wellcome Trust Sanger Institute
(Cambridge, UK).
References
When making use of these data, please cite:
Griffiths-Jones S.
The microRNA Registry.
Nucleic Acids Res. 2004 Jan 1;32(Database issue):D109-11.
PMID: 14681370; PMC: PMC308757
Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A, Enright AJ.
miRBase: microRNA sequences, targets and gene nomenclature.
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4.
PMID: 16381832; PMC: PMC1347474
Weber MJ.
New human and mouse microRNA genes found by homology search.
FEBS J. 2005 Jan;272(1):59-73.
PMID: 15634332
The following publication provides guidelines on miRNA annotation:
Ambros V, Bartel B, Bartel DP, Burge CB, Carrington JC, Chen X, Dreyfuss G, Eddy SR, Griffiths-Jones
S, Marshall M et al.
A uniform system for microRNA annotation.
RNA. 2003 Mar;9(3):277-9.
PMID: 12592000; PMC: PMC1370393
For more information on blat, see
Kent WJ.
BLAT--the BLAST-like alignment tool.
Genome Res. 2002 Apr;12(4):656-64.
PMID: 11932250; PMC: PMC187518
|