Chemical modifications (e.g. methylation and acylation) to the histone proteins
present in chromatin influence gene expression by changing how
accessible the chromatin is to transcription. A specific modification of
a specific histone protein is called a histone mark.
This track shows the levels of enrichment of the H3K27Ac histone mark across the genome as determined by a
ChIP-seq assay. The H3K27Ac histone mark is the acetylation of lysine 27 of the H3 histone
protein, and it is thought to enhance transcription possibly by blocking the
spread of the repressive histone mark H3K27Me3. Additional histone marks and other chromatin
associated ChIP-seq data is available at the
Broad Histone page.
By default this track uses a transparent overlay method of displaying data from a number of cell
lines in the same vertical space. Each of the cell lines in this track is associated with a particular
color, and these cell line colors are consistent across all tracks that
are part of the ENCODE Regulation supertrack.
These colors are relatively light and saturated so as to work best with the transparent overlay.
Unfortunately, outside the ENCODE Regulation tracks, older cell line
color conventions are used that don't match the cell line colors used in
the ENCODE Regulation tracks. The older colors were not used in the
ENCODE Regulation tracks because they were too dark for the transparent
This track shows data from the Bernstein Lab at the Broad Institute. The Bernstein lab is part of
the ENCODE consortium.
Data Release Policy
Data users may freely use ENCODE data, but may not, without prior
consent, submit publications that use an unpublished ENCODE dataset until
nine months following the release of the dataset. This date is listed in
the Restricted Until column, above. The full data release policy
for ENCODE is available