Gencode Genes

PSENEN (ENST00000222266.2) at chr19:35745619-35747004 - Essential subunit of the gamma-secretase complex, an  endoprotease complex that catalyzes the intramembrane cleavage of  integral membrane proteins such as Notch receptors and APP (beta-  amyloid precursor protein). Probably represents the last step of  maturation of gamma-secretase, facilitating endoproteolysis of  presenilin and conferring gamma-secretase activity. (from UniProt Q9NZ42)