Non-Mouse RefSeq Gene
 

Non-Mouse RefSeq Gene IL22RA2

RefSeq: NM_181310.2   Status: Reviewed
Description: Homo sapiens interleukin 22 receptor subunit alpha 2 (IL22RA2), transcript variant 3, mRNA.
Organism: Homo sapiens
UCSC browser: NM_181310 on Human (hg38)
CDS: 3' complete
OMIM: 606648
Entrez Gene: 116379
PubMed on Gene: IL22RA2
PubMed on Product: interleukin-22 receptor subunit alpha-2 isoform 3 precursor

Summary of IL22RA2

This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013].


mRNA/Genomic Alignments

BROWSER | SIZE IDENTITY CHROMOSOME  STRAND    START     END              QUERY      START  END  TOTAL
-----------------------------------------------------------------------------------------------------
browser |   658   79.7%         10     ++  19622022  19634029             NM_181310   280  1923  2627

Position: chr10:19622022-19634029
Band: 10qA3
Genomic Size: 12008
Strand: +
Gene Symbol: IL22RA2
CDS Start: complete
CDS End: complete

Links to sequence:

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Data last updated at UCSC: 2020-08-17

Description

This track shows known protein-coding and non-protein-coding genes for organisms other than mouse, taken from the NCBI RNA reference sequences collection (RefSeq). The data underlying this track are updated weekly.

Display Conventions and Configuration

This track follows the display conventions for gene prediction tracks. The color shading indicates the level of review the RefSeq record has undergone: predicted (light), provisional (medium), reviewed (dark).

The item labels and display colors of features within this track can be configured through the controls at the top of the track description page.

  • Label: By default, items are labeled by gene name. Click the appropriate Label option to display the accession name instead of the gene name, show both the gene and accession names, or turn off the label completely.
  • Codon coloring: This track contains an optional codon coloring feature that allows users to quickly validate and compare gene predictions. To display codon colors, select the genomic codons option from the Color track by codons pull-down menu. Click here for more information about this feature.
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Methods

The RNAs were aligned against the mouse genome using blat; those with an alignment of less than 15% were discarded. At least 40 bases must be aligned to DNA that is not repeat masked. When a single RNA aligned in multiple places, the alignment having the highest base identity was identified. Only alignments having a base identity level within 1.0% of the best and at least 35% base identity with the genomic sequence were kept.

Credits

This track was produced at UCSC from RNA sequence data generated by scientists worldwide and curated by the NCBI RefSeq project.

References

Kent WJ. BLAT--the BLAST-like alignment tool. Genome Res. 2002 Apr;12(4):656-64. PMID: 11932250; PMC: PMC187518