Non-Human RefSeq Gene

Non-Human RefSeq Gene Cpvl

RefSeq: NM_027749.2   Status: Reviewed
Description: Mus musculus carboxypeptidase, vitellogenic-like (Cpvl), transcript variant 1, mRNA.
Organism: Mus musculus
UCSC browser: NM_027749 on Mouse (mm10)
CDS: completeness unknown
Entrez Gene: 71287
PubMed on Gene: Cpvl
PubMed on Product: probable serine carboxypeptidase CPVL isoform 1 precursor
GeneCards: Cpvl
AceView: Cpvl

Summary of Cpvl

This gene encodes a member of the serine carboxypeptidase family of proteases that cleave amino acids from the C-terminus of a protein substrate. The human ortholog of this gene, where it was first characterized, was found to be upregulated during the maturation of monocytes to macrophages. The encoded protein may be involved in antigen processing, digestion of phagocytosed proteins in the lysosome and lamellipodium formation. Disruption of this gene in mice was found to cause embryonic lethality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].

mRNA/Genomic Alignments

browser |  1264   80.4%          7     +-  28995757  29112811             NM_027749   323  1588  1708

Position: chr7:28995757-29112811
Band: 7p14.3
Genomic Size: 117055
Strand: -
Gene Symbol: Cpvl
CDS Start: complete
CDS End: not complete

Links to sequence:

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Data last updated: 2019-10-03

p12 Note: Includes annotations on GRCh38.p12 patch sequences


This track shows known protein-coding and non-protein-coding genes for organisms other than human, taken from the NCBI RNA reference sequences collection (RefSeq). The data underlying this track are updated weekly.

Display Conventions and Configuration

This track follows the display conventions for gene prediction tracks. The color shading indicates the level of review the RefSeq record has undergone: predicted (light), provisional (medium), reviewed (dark).

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  • Codon coloring: This track contains an optional codon coloring feature that allows users to quickly validate and compare gene predictions. To display codon colors, select the genomic codons option from the Color track by codons pull-down menu. For more information about this feature, go to the Coloring Gene Predictions and Annotations by Codon page.
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The RNAs were aligned against the human genome using blat; those with an alignment of less than 15% were discarded. When a single RNA aligned in multiple places, the alignment having the highest base identity was identified. Only alignments having a base identity level within 0.5% of the best and at least 25% base identity with the genomic sequence were kept.


This track was produced at UCSC from RNA sequence data generated by scientists worldwide and curated by the NCBI RefSeq project.


Kent WJ. BLAT--the BLAST-like alignment tool. Genome Res. 2002 Apr;12(4):656-64. PMID: 11932250; PMC: PMC187518

Pruitt KD, Brown GR, Hiatt SM, Thibaud-Nissen F, Astashyn A, Ermolaeva O, Farrell CM, Hart J, Landrum MJ, McGarvey KM et al. RefSeq: an update on mammalian reference sequences. Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63. PMID: 24259432; PMC: PMC3965018

Pruitt KD, Tatusova T, Maglott DR. NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4. PMID: 15608248; PMC: PMC539979