Human Gene SLC35A3 (uc001dsp.1)
  Description: solute carrier family 35 member 3A
RefSeq Summary (NM_012243): This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].
Transcript (Including UTRs)
   Position: hg18 chr1:100,208,128-100,261,594 Size: 53,467 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg18 chr1:100,231,699-100,260,620 Size: 28,922 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:100,208,128-100,261,594)mRNA (may differ from genome)Protein (325 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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PubMedReactomeTreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: S35A3_HUMAN
DESCRIPTION: RecName: Full=UDP-N-acetylglucosamine transporter; AltName: Full=Golgi UDP-GlcNAc transporter; AltName: Full=Solute carrier family 35 member A3;
FUNCTION: Uridine diphosphate-N-acetylglucosamine transporter in the Golgi apparatus.
SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -97.00197-0.492 Picture PostScript Text
3' UTR -203.89974-0.209 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007271 - Nuc_sug_transpt
IPR021189 - UDP/CMP-sugar_transptr
IPR004689 - UDPgal_transpt

Pfam Domains:
PF04142 - Nucleotide-sugar transporter

SCOP Domains:
103481 - Multidrug resistance efflux transporter EmrE

ModBase Predicted Comparative 3D Structure on Q9Y2D2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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MGIRGD    
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity
GO:0005515 protein binding
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity

Biological Process:
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0008643 carbohydrate transport
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport
GO:1990569 UDP-N-acetylglucosamine transmembrane transport

Cellular Component:
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AB021981 - Homo sapiens mRNA for UDP-N-acetylglucosamine transporter, complete cds.
BC005136 - Homo sapiens solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3, mRNA (cDNA clone MGC:1421 IMAGE:3505772), complete cds.
AK290573 - Homo sapiens cDNA FLJ76111 complete cds, highly similar to Homo sapiens solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 (SLC35A3), mRNA.
CR749816 - Homo sapiens mRNA; cDNA DKFZp781P1297 (from clone DKFZp781P1297).
AK024989 - Homo sapiens cDNA: FLJ21336 fis, clone COL02551, highly similar to AB021981 Homo sapiens mRNA for UDP-N-acetylglucosamine transporter.
JD507381 - Sequence 488405 from Patent EP1572962.
KJ902341 - Synthetic construct Homo sapiens clone ccsbBroadEn_11735 SLC35A3 gene, encodes complete protein.
JD110795 - Sequence 91819 from Patent EP1572962.
JD297464 - Sequence 278488 from Patent EP1572962.
JD292172 - Sequence 273196 from Patent EP1572962.
JD298662 - Sequence 279686 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9Y2D2 (Reactome details) participates in the following event(s):

R-HSA-741450 SLC35A3 exchanges UDP-GlcNAc for UMP
R-HSA-727802 Metabolism of sugars
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: NM_012243, NP_036375, Q68CR2, Q9Y2D2, S35A3_HUMAN
UCSC ID: uc001dsp.1
RefSeq Accession: NM_012243
Protein: Q9Y2D2 (aka S35A3_HUMAN)
CCDS: CCDS762.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_012243.1
exon count: 8CDS single in 3' UTR: no RNA size: 2149
ORF size: 978CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2149.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.