ID:EXTL2_HUMAN DESCRIPTION: RecName: Full=Exostosin-like 2; EC=188.8.131.52; AltName: Full=Alpha-1,4-N-acetylhexosaminyltransferase EXTL2; AltName: Full=Alpha-GalNAcT EXTL2; AltName: Full=EXT-related protein 2; AltName: Full=Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Contains: RecName: Full=Processed exostosin-like 2; FUNCTION: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D- glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl- (1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D- glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl- (1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan. PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity). SUBCELLULAR LOCATION: Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum. TISSUE SPECIFICITY: Ubiquitous. PTM: The soluble form derives from the membrane form by proteolytic processing. SIMILARITY: Belongs to the glycosyltransferase 47 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/"; WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=Exostosin-like 2; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_530";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UBQ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.