Description: zinc transporter like 2 RefSeq Summary (NM_001144884): Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]. Transcript (Including UTRs) Position: hg18 chr1:101,134,266-101,217,579 Size: 83,314 Total Exon Count: 12 Strand: + Coding Region Position: hg18 chr1:101,134,407-101,213,001 Size: 78,595 Coding Exon Count: 11
ID:ZNT7_HUMAN DESCRIPTION: RecName: Full=Zinc transporter 7; Short=ZnT-7; AltName: Full=Solute carrier family 30 member 7; AltName: Full=Znt-like transporter 2; FUNCTION: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). SUBUNIT: Homooligomer. INTERACTION: P25942:CD40; NbExp=1; IntAct=EBI-1043569, EBI-525714; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. INDUCTION: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down- regulation of gene expression. Up-regulated by zinc depletion. SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NEW0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BX537375 - Homo sapiens mRNA; cDNA DKFZp686D18111 (from clone DKFZp686D18111); complete cds. CR936806 - Homo sapiens mRNA; cDNA DKFZp686M0368 (from clone DKFZp686M0368). AK313638 - Homo sapiens cDNA, FLJ94211, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 7(SLC30A7), mRNA. BC064692 - Homo sapiens solute carrier family 30 (zinc transporter), member 7, mRNA (cDNA clone MGC:71576 IMAGE:30330665), complete cds. AF233345 - Homo sapiens zinc transporter-like 2 protein mRNA, complete cds. AB463270 - Synthetic construct DNA, clone: pF1KB8705, Homo sapiens SLC30A7 gene for solute carrier family 30 (zinc transporter), member 7, without stop codon, in Flexi system. AF529197 - Homo sapiens zinc transporter ZNT7 (ZNT7) mRNA, partial cds. AM392927 - Synthetic construct Homo sapiens clone IMAGE:100003076 for hypothetical protein (SLC30A7 gene). AY094606 - Homo sapiens zinc transporter ZnT-7 (ZNT7) mRNA, complete cds. BX648884 - Homo sapiens mRNA; cDNA DKFZp686M01243 (from clone DKFZp686M01243). AK023089 - Homo sapiens cDNA FLJ13027 fis, clone NT2RP3001007. JD404122 - Sequence 385146 from Patent EP1572962. JD536133 - Sequence 517157 from Patent EP1572962. JD374548 - Sequence 355572 from Patent EP1572962. JD489164 - Sequence 470188 from Patent EP1572962. JD489165 - Sequence 470189 from Patent EP1572962. JD519110 - Sequence 500134 from Patent EP1572962. JD396186 - Sequence 377210 from Patent EP1572962. JD409294 - Sequence 390318 from Patent EP1572962. JD280819 - Sequence 261843 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8NEW0 (Reactome details) participates in the following event(s):
R-HSA-437129 ZnT7 transports zinc into the golgi apparatus R-HSA-264876 Insulin processing R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family R-HSA-2980736 Peptide hormone metabolism R-HSA-435354 Zinc transporters R-HSA-392499 Metabolism of proteins R-HSA-425410 Metal ion SLC transporters R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules
US Server
