Human Gene SLC30A7 (uc001dtn.1)
  Description: zinc transporter like 2
RefSeq Summary (NM_001144884): Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008].
Transcript (Including UTRs)
   Position: hg18 chr1:101,134,266-101,217,579 Size: 83,314 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg18 chr1:101,134,407-101,213,001 Size: 78,595 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:101,134,266-101,217,579)mRNA (may differ from genome)Protein (376 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsH-INV
HGNCMGIOMIMPubMedReactomeTreefam
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZNT7_HUMAN
DESCRIPTION: RecName: Full=Zinc transporter 7; Short=ZnT-7; AltName: Full=Solute carrier family 30 member 7; AltName: Full=Znt-like transporter 2;
FUNCTION: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
SUBUNIT: Homooligomer.
INTERACTION: P25942:CD40; NbExp=1; IntAct=EBI-1043569, EBI-525714;
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
INDUCTION: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down- regulation of gene expression. Up-regulated by zinc depletion.
SIMILARITY: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -52.30141-0.371 Picture PostScript Text
3' UTR -1076.434262-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002524 - Cation_efflux

Pfam Domains:
PF01545 - Cation efflux family

ModBase Predicted Comparative 3D Structure on Q8NEW0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
     SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005385 zinc ion transmembrane transporter activity
GO:0008324 cation transmembrane transporter activity

Biological Process:
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006829 zinc II ion transport
GO:0010043 response to zinc ion
GO:0032119 sequestering of zinc ion
GO:0055085 transmembrane transport
GO:0061088 regulation of sequestering of zinc ion
GO:0071577 zinc II ion transmembrane transport
GO:0098655 cation transmembrane transport

Cellular Component:
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  BX537375 - Homo sapiens mRNA; cDNA DKFZp686D18111 (from clone DKFZp686D18111); complete cds.
CR936806 - Homo sapiens mRNA; cDNA DKFZp686M0368 (from clone DKFZp686M0368).
AK313638 - Homo sapiens cDNA, FLJ94211, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 7(SLC30A7), mRNA.
BC064692 - Homo sapiens solute carrier family 30 (zinc transporter), member 7, mRNA (cDNA clone MGC:71576 IMAGE:30330665), complete cds.
AF233345 - Homo sapiens zinc transporter-like 2 protein mRNA, complete cds.
AB463270 - Synthetic construct DNA, clone: pF1KB8705, Homo sapiens SLC30A7 gene for solute carrier family 30 (zinc transporter), member 7, without stop codon, in Flexi system.
AF529197 - Homo sapiens zinc transporter ZNT7 (ZNT7) mRNA, partial cds.
AM392927 - Synthetic construct Homo sapiens clone IMAGE:100003076 for hypothetical protein (SLC30A7 gene).
AY094606 - Homo sapiens zinc transporter ZnT-7 (ZNT7) mRNA, complete cds.
BX648884 - Homo sapiens mRNA; cDNA DKFZp686M01243 (from clone DKFZp686M01243).
AK023089 - Homo sapiens cDNA FLJ13027 fis, clone NT2RP3001007.
JD404122 - Sequence 385146 from Patent EP1572962.
JD536133 - Sequence 517157 from Patent EP1572962.
JD374548 - Sequence 355572 from Patent EP1572962.
JD489164 - Sequence 470188 from Patent EP1572962.
JD489165 - Sequence 470189 from Patent EP1572962.
JD519110 - Sequence 500134 from Patent EP1572962.
JD396186 - Sequence 377210 from Patent EP1572962.
JD409294 - Sequence 390318 from Patent EP1572962.
JD280819 - Sequence 261843 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8NEW0 (Reactome details) participates in the following event(s):

R-HSA-437129 ZnT7 transports zinc into the golgi apparatus
R-HSA-264876 Insulin processing
R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family
R-HSA-2980736 Peptide hormone metabolism
R-HSA-435354 Zinc transporters
R-HSA-392499 Metabolism of proteins
R-HSA-425410 Metal ion SLC transporters
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: CR936806, NM_133496, NP_598003, Q8NEW0, Q8TCH2, ZNT7, ZNT7_HUMAN, ZNTL2
UCSC ID: uc001dtn.1
RefSeq Accession: NM_001144884
Protein: Q8NEW0 (aka ZNT7_HUMAN)
CCDS: CCDS776.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: CR936806.1
exon count: 12CDS single in 3' UTR: no RNA size: 5591
ORF size: 1131CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2462.00frame shift in genome: no % Coverage: 98.89
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.