Description: Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA. RefSeq Summary (NM_000686): The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus and in neonates, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked cognitive disability. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2 infection results in down-regulation of angiotensin converting enzyme-2 (ACE2) receptors, the effects of which, triggers serious inflammatory lesions in the tissues involved, primarily in the lungs. The inflammatory reaction appears to be mediated by angiotensin II derivatives, including the angiotensin AT2 receptor which has been found to be upregulated in bronchoalveolar lavage samples from Coronavirus disease 2019 (COVID19) patients. [provided by RefSeq, Jul 2020]. Transcript (Including UTRs) Position: hg19 chrX:115,301,958-115,306,225 Size: 4,268 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chrX:115,303,534-115,304,625 Size: 1,092 Coding Exon Count: 1
ID:AGTR2_HUMAN DESCRIPTION: RecName: Full=Type-2 angiotensin II receptor; AltName: Full=Angiotensin II type-2 receptor; Short=AT2; FUNCTION: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. SUBUNIT: Interacts with MTUS1. INTERACTION: P35625:TIMP3; NbExp=7; IntAct=EBI-1748067, EBI-1748085; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: In adult, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Expressed in the cerebellum. Very highly expressed in fetal kidney and intestine. DISEASE: Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88) [MIM:300852]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AGTR2";
blood pressure, arterial body mass glucose tolerance lipids Kotani, K. et al. 2007, The angiotensin II type 2 receptor gene polymorphism and body mass index in healthy Japanese women, Ann Clin Biochem 2007 44(1) 83-85.
[PubMed 17270098]
These findings suggest that the AT2-R A/C(3123) polymorphism could be a polymorphic marker related to BMI in Japanese women.
congenital anomalies; renal disease Rigoli, L. et al. 2004, Angiotensin-converting enzyme and angiotensin type 2 receptor gene genotype distributions in Italian children with congenital uropathies., Pediatric research. 2004 Dec;56(6):988-93.
[PubMed 15470205]
Our findings indicate that the ACE gene can be a risk factor in the progression of renal parenchymal damage in CAKUT patients. Moreover, a major role of the AT2R gene in the development of CAKUT has been found, at least in Italian children.
hypertension Jin, J. J. et al. 2003, Association of angiotensin II type 2 receptor gene variant with hypertension, Hypertension research. 2003 Jul;26(7):547-52.
[PubMed 12924622]
This analysis showed that the C4599A polymorphism was associated with hypertension in women (p=0.0058), but not in men. Moreover, this female-specific association was pronounced in premenopausal women. The female-specific association may be helpful in conducting further molecular and biological studies on the relationship among sex, the renin-angiotensin system, and hypertension.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P50052
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004945 angiotensin type II receptor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0017046 peptide hormone binding GO:0048019 receptor antagonist activity
Biological Process: GO:0001822 kidney development GO:0001974 blood vessel remodeling GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0002018 renin-angiotensin regulation of aldosterone production GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure GO:0002035 brain renin-angiotensin system GO:0006883 cellular sodium ion homeostasis GO:0006954 inflammatory response GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007186 G-protein coupled receptor signaling pathway GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007263 nitric oxide mediated signal transduction GO:0007420 brain development GO:0008217 regulation of blood pressure GO:0008284 positive regulation of cell proliferation GO:0010243 response to organonitrogen compound GO:0010459 negative regulation of heart rate GO:0010700 negative regulation of norepinephrine secretion GO:0021695 cerebellar cortex development GO:0030308 negative regulation of cell growth GO:0032304 negative regulation of icosanoid secretion GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0035556 intracellular signal transduction GO:0035566 regulation of metanephros size GO:0035640 exploration behavior GO:0035815 positive regulation of renal sodium excretion GO:0035932 aldosterone secretion GO:0038166 angiotensin-activated signaling pathway GO:0042306 regulation of protein import into nucleus GO:0042311 vasodilation GO:0042416 dopamine biosynthetic process GO:0042981 regulation of apoptotic process GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045893 positive regulation of transcription, DNA-templated GO:0048147 negative regulation of fibroblast proliferation GO:0050715 positive regulation of cytokine secretion GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway GO:0060993 kidney morphogenesis GO:0061049 cell growth involved in cardiac muscle cell development GO:0071549 cellular response to dexamethasone stimulus GO:0072300 positive regulation of metanephric glomerulus development GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0097746 regulation of blood vessel diameter GO:1900116 extracellular negative regulation of signal transduction GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
LF211444 - JP 2014500723-A/18947: Polycomb-Associated Non-Coding RNAs. AK313927 - Homo sapiens cDNA, FLJ94566, Homo sapiens angiotensin II receptor, type 2 (AGTR2), mRNA. X87723 - H.sapiens mRNA for angiotensin ii type receptor, mRNA, 5' untranslated region. LF214067 - JP 2014500723-A/21570: Polycomb-Associated Non-Coding RNAs. U16957 - Human angiotensin II type 2 receptor mRNA, complete cds. BC095504 - Homo sapiens angiotensin II receptor, type 2, mRNA (cDNA clone MGC:111714 IMAGE:6971944), complete cds. LF379648 - JP 2014500723-A/187151: Polycomb-Associated Non-Coding RNAs. AB463410 - Synthetic construct DNA, clone: pF1KB7158, Homo sapiens AGTR2 gene for angiotensin II receptor, type 2, without stop codon, in Flexi system. CR541969 - Homo sapiens full open reading frame cDNA clone RZPDo834H1034D for gene AGTR2, angiotensin II receptor, type 2; complete cds, without stopcodon. LF379649 - JP 2014500723-A/187152: Polycomb-Associated Non-Coding RNAs. LF379650 - JP 2014500723-A/187153: Polycomb-Associated Non-Coding RNAs. LF379651 - JP 2014500723-A/187154: Polycomb-Associated Non-Coding RNAs. LF379652 - JP 2014500723-A/187155: Polycomb-Associated Non-Coding RNAs. LF379653 - JP 2014500723-A/187156: Polycomb-Associated Non-Coding RNAs. JD493463 - Sequence 474487 from Patent EP1572962. LF379654 - JP 2014500723-A/187157: Polycomb-Associated Non-Coding RNAs. LF379655 - JP 2014500723-A/187158: Polycomb-Associated Non-Coding RNAs. JD084689 - Sequence 65713 from Patent EP1572962. JD063596 - Sequence 44620 from Patent EP1572962. JD350397 - Sequence 331421 from Patent EP1572962. MA449644 - JP 2018138019-A/21570: Polycomb-Associated Non-Coding RNAs. MA447021 - JP 2018138019-A/18947: Polycomb-Associated Non-Coding RNAs. MA615225 - JP 2018138019-A/187151: Polycomb-Associated Non-Coding RNAs. MA615226 - JP 2018138019-A/187152: Polycomb-Associated Non-Coding RNAs. MA615227 - JP 2018138019-A/187153: Polycomb-Associated Non-Coding RNAs. MA615228 - JP 2018138019-A/187154: Polycomb-Associated Non-Coding RNAs. MA615229 - JP 2018138019-A/187155: Polycomb-Associated Non-Coding RNAs. MA615230 - JP 2018138019-A/187156: Polycomb-Associated Non-Coding RNAs. MA615231 - JP 2018138019-A/187157: Polycomb-Associated Non-Coding RNAs. MA615232 - JP 2018138019-A/187158: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction hsa04614 - Renin-angiotensin system
BioCarta from NCI Cancer Genome Anatomy Project h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway h_cardiacegfPathway - Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy h_ace2Pathway - Angiotensin-converting enzyme 2 regulates heart function
Reactome (by CSHL, EBI, and GO)
Protein P50052 (Reactome details) participates in the following event(s):
R-HSA-374173 Angiotensin II binds to angiotensin II receptor (types 1 and 2) R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-375276 Peptide ligand-binding receptors R-HSA-418594 G alpha (i) signalling events R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
