Human Gene MICOS13 (uc002mch.1)
  Description: Homo sapiens chromosome 19 open reading frame 70 (MICOS13), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:5,678,433-5,680,911 Size: 2,479 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr19:5,678,562-5,680,497 Size: 1,936 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:5,678,433-5,680,911)mRNA (may differ from genome)Protein (118 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHPRDLynxMGIneXtProtOMIM
PubMedReactomeTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QIL1_HUMAN
DESCRIPTION: RecName: Full=Protein QIL1; AltName: Full=Protein P117;
INTERACTION: Q9BRX2:PELO; NbExp=1; IntAct=EBI-1053887, EBI-1043580;
SIMILARITY: Belongs to the UPF0433 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 65.69 RPKM in Testis
Total median expression: 1401.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -178.22414-0.430 Picture PostScript Text
3' UTR -55.10129-0.427 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026769 - QIL1

Pfam Domains:
PF15884 - Protein QIL1

ModBase Predicted Comparative 3D Structure on Q5XKP0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
  Protein Sequence   
  Alignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0042407 cristae formation

Cellular Component:
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0044284 mitochondrial crista junction
GO:0061617 MICOS complex


-  Descriptions from all associated GenBank mRNAs
  BC052640 - Homo sapiens hypothetical protein P117, mRNA (cDNA clone IMAGE:5220638).
BC009557 - Homo sapiens chromosome 19 open reading frame 70, mRNA (cDNA clone MGC:10110 IMAGE:3899541), complete cds.
BC042386 - Homo sapiens chromosome 19 open reading frame 70, mRNA (cDNA clone MGC:57483 IMAGE:5288954), complete cds.
KJ895410 - Synthetic construct Homo sapiens clone ccsbBroadEn_04804 C19orf70 gene, encodes complete protein.
AK091768 - Homo sapiens cDNA FLJ34449 fis, clone HLUNG2002145.
AX747173 - Sequence 698 from Patent EP1308459.
JD074538 - Sequence 55562 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q5XKP0 (Reactome details) participates in the following event(s):

R-HSA-8949613 Cristae formation
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: C19orf70, NM_205767, NP_991330, Q5XKP0, Q86YE5, QIL1, QIL1_HUMAN, uc002mci.1
UCSC ID: uc002mch.1
RefSeq Accession: NM_205767
Protein: Q5XKP0 (aka QIL1_HUMAN)
CCDS: CCDS12143.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_205767.1
exon count: 4CDS single in 3' UTR: no RNA size: 943
ORF size: 357CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 885.00frame shift in genome: no % Coverage: 95.44
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.