Description: Homo sapiens cyclin C (CCNC), transcript variant 1, mRNA. RefSeq Summary (NM_005190): The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr6:99,990,263-100,016,690 Size: 26,428 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr6:99,991,431-100,016,403 Size: 24,973 Coding Exon Count: 12
ID:CCNC_HUMAN DESCRIPTION: RecName: Full=Cyclin-C; AltName: Full=SRB11 homolog; Short=hSRB11; FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II. INTERACTION: P49336:CDK8; NbExp=3; IntAct=EBI-395261, EBI-394377; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily. SIMILARITY: Contains 1 cyclin N-terminal domain. SEQUENCE CAUTION: Sequence=AAC50825.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P24863
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004674 protein serine/threonine kinase activity GO:0005515 protein binding GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006468 protein phosphorylation GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain
BC050726 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:6165083), containing frame-shift errors. AK222768 - Homo sapiens mRNA, CCNC protein variant, clone: HEP00488. BC030159 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:5022155), partial cds. BC056153 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:65052 IMAGE:6157106), complete cds. BC010135 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:19502 IMAGE:4106819), complete cds. BC041123 - Homo sapiens cyclin C, mRNA (cDNA clone MGC:47670 IMAGE:5759974), complete cds. AK223247 - Homo sapiens mRNA, CCNC protein variant, clone: STM05973. AK291914 - Homo sapiens cDNA FLJ77471 complete cds, highly similar to Homo sapiens cyclin C (CCNC), transcript variant 1, mRNA. M74091 - Human cyclin mRNA. AK298558 - Homo sapiens cDNA FLJ52012 complete cds, highly similar to Cyclin-C. AB125137 - Homo sapiens CCNC mRNA for cyclin C, complete cds. CU691126 - Synthetic construct Homo sapiens gateway clone IMAGE:100021712 5' read CCNC mRNA. HQ448076 - Synthetic construct Homo sapiens clone IMAGE:100071456; CCSB011984_02 cyclin C (CCNC) gene, encodes complete protein. KJ890842 - Synthetic construct Homo sapiens clone ccsbBroadEn_00236 CCNC gene, encodes complete protein. KJ896553 - Synthetic construct Homo sapiens clone ccsbBroadEn_05947 CCNC gene, encodes complete protein. AB528579 - Synthetic construct DNA, clone: pF1KE0097, Homo sapiens CCNC gene for cyclin C, without stop codon, in Flexi system. CU679631 - Synthetic construct Homo sapiens gateway clone IMAGE:100022392 5' read CCNC mRNA. BC026272 - Homo sapiens cyclin C, mRNA (cDNA clone IMAGE:4250420), partial cds. AK130983 - Homo sapiens cDNA FLJ27473 fis, clone DMC06528. JD509130 - Sequence 490154 from Patent EP1572962. JD439078 - Sequence 420102 from Patent EP1572962. JD101608 - Sequence 82632 from Patent EP1572962. JD034432 - Sequence 15456 from Patent EP1572962. JD019534 - Sequence 558 from Patent EP1572962. JD023807 - Sequence 4831 from Patent EP1572962. JD025953 - Sequence 6977 from Patent EP1572962. JD022448 - Sequence 3472 from Patent EP1572962. JD032834 - Sequence 13858 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P24863 (Reactome details) participates in the following event(s):
R-HSA-212352 Formation of ARC coactivator complex R-HSA-212380 Formation of TRAP coactivator complex R-HSA-212432 Formation of DRIP coactivator complex R-HSA-381309 PPARG:RXRA heterodimer binds to fatty acid-like ligands R-HSA-1912393 MAML in complex with NICD1 recruits CDK8 R-NUL-2064916 MAML recruits CDK8:CCNC to xNICD1 R-HSA-2220957 NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC R-HSA-1912391 NICD1 is phosphorylated by CDK8 R-NUL-2065178 CDK8 phosphorylates xNICD1 R-HSA-2220971 CDK8 phosphorylates NICD1 PEST domain mutants R-HSA-2176475 Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 R-HSA-212436 Generic Transcription Pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-73857 RNA Polymerase II Transcription R-HSA-1266738 Developmental Biology R-HSA-1980143 Signaling by NOTCH1 R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-74160 Gene expression (Transcription) R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription R-HSA-157118 Signaling by NOTCH R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-162582 Signal Transduction R-HSA-5663202 Diseases of signal transduction R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-1643685 Disease R-HSA-9006936 Signaling by TGF-beta family members
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
