Description: Homo sapiens component of oligomeric golgi complex 5 (COG5), transcript variant 1, mRNA. RefSeq Summary (NM_006348): The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]. Sequence Note:. Transcript (Including UTRs) Position: hg19 chr7:106,842,189-107,204,959 Size: 362,771 Total Exon Count: 22 Strand: - Coding Region Position: hg19 chr7:106,843,961-107,204,434 Size: 360,474 Coding Exon Count: 22
Osteoarthritis Hanneke J M Kerkhof et al. Arthritis and rheumatism 2010, A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22., Arthritis and rheumatism.
[PubMed 20112360]
Our findings identify a novel common variant on chromosome 7q22 that influences susceptibility to prevalence and progression of OA. Since the GPR22 gene encodes a G protein-coupled receptor, this is potentially an interesting therapeutic target.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UP83-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK022835 - Homo sapiens cDNA FLJ12773 fis, clone NT2RP2001660, highly similar to Conserved oligomeric Golgi complex component 5. AF058718 - Homo sapiens putative 13 S Golgi transport complex 90kD subunit brain-specific isoform mRNA, complete cds. AK314270 - Homo sapiens cDNA, FLJ95023. BC068540 - Homo sapiens component of oligomeric golgi complex 5, mRNA (cDNA clone MGC:87389 IMAGE:4374289), complete cds. HQ258000 - Synthetic construct Homo sapiens clone IMAGE:100072309 component of oligomeric golgi complex 5 (COG5), transcript variant 3 (COG5) gene, encodes complete protein. KJ898221 - Synthetic construct Homo sapiens clone ccsbBroadEn_07615 COG5 gene, encodes complete protein. LF209511 - JP 2014500723-A/17014: Polycomb-Associated Non-Coding RNAs. LF213998 - JP 2014500723-A/21501: Polycomb-Associated Non-Coding RNAs. MA449575 - JP 2018138019-A/21501: Polycomb-Associated Non-Coding RNAs. MA445088 - JP 2018138019-A/17014: Polycomb-Associated Non-Coding RNAs. AK123726 - Homo sapiens cDNA FLJ41732 fis, clone HLUNG2017546. JD090183 - Sequence 71207 from Patent EP1572962. JD235501 - Sequence 216525 from Patent EP1572962. JD309860 - Sequence 290884 from Patent EP1572962. JD217142 - Sequence 198166 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9UP83 (Reactome details) participates in the following event(s):
R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6811433 The COG tethering complex interacts with numerous SNAREs at the Golgi membrane R-HSA-8847544 The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering R-HSA-8849748 The COG complex binds RABs at the Golgi membrane R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811438 Intra-Golgi traffic R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
