Description: Homo sapiens guanine nucleotide binding protein (G protein), alpha z polypeptide (GNAZ), mRNA. RefSeq Summary (NM_002073): The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr22:23,412,669-23,467,221 Size: 54,553 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr22:23,437,883-23,465,618 Size: 27,736 Coding Exon Count: 2
ID:GNAZ_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(z) subunit alpha; AltName: Full=G(x) alpha chain; AltName: Full=Gz-alpha; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19086
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P19086 (Reactome details) participates in the following event(s):
R-HSA-392064 G alpha (z) inhibits adenylate cyclase R-HSA-392133 G alpha (z) auto-inactivates by hydrolysing GTP to GDP R-HSA-8982703 PKC binds active G alpha (z) R-HSA-751024 The Ligand:GPCR:Gz complex dissociates R-HSA-750988 Inactive G alpha (z) reassociates with G beta:gamma R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL R-HSA-8982709 G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) R-HSA-751040 PKC phosphorylates G alpha (z) R-HSA-749446 Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit R-HSA-112037 Inactivation of PLC beta R-HSA-167415 G-protein alpha subunit is inactivated R-HSA-111870 Activation of PLC beta-1/4 R-HSA-112271 The receptor:G-protein complex dissociates R-HSA-167429 The receptor:G-protein complex binds GTP R-HSA-749453 Liganded Gz-activating GPCR acts as a GEF for Gz R-HSA-167408 The high affinity receptor complex binds to G-protein R-HSA-167419 The receptor:G-protein complex releases GDP R-HSA-111879 PIP2 hydrolysis R-HSA-418597 G alpha (z) signalling events R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-388396 GPCR downstream signalling R-HSA-202040 G-protein activation R-HSA-112043 PLC beta mediated events R-HSA-390466 Chaperonin-mediated protein folding R-HSA-372790 Signaling by GPCR R-HSA-111885 Opioid Signalling R-HSA-112040 G-protein mediated events R-HSA-391251 Protein folding R-HSA-162582 Signal Transduction R-HSA-418594 G alpha (i) signalling events R-HSA-392499 Metabolism of proteins