Description: Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (PSMD6), transcript variant 1, mRNA. RefSeq Summary (NM_001271779): This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]. Transcript (Including UTRs) Position: hg19 chr3:63,996,225-64,009,282 Size: 13,058 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr3:63,996,344-64,009,095 Size: 12,752 Coding Exon Count: 9
Diabetes Mellitus, Type 2 Yoon Shin Cho et al. Nature genetics 2012, Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians., Nature genetics.
[PubMed 22158537]
Folic Acid Toshiko Tanaka et al. American journal of human genetics 2009, Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations., American journal of human genetics.
[PubMed 19303062]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on C9IZE4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.