Description: Homo sapiens scribbled planar cell polarity protein (SCRIB), transcript variant 1, mRNA. RefSeq Summary (NM_182706): This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Transcript (Including UTRs) Position: hg19 chr8:144,873,090-144,897,549 Size: 24,460 Total Exon Count: 37 Strand: - Coding Region Position: hg19 chr8:144,873,333-144,897,542 Size: 24,210 Coding Exon Count: 37
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00595 - PDZ domain (Also known as DHR or GLGF) PF13180 - PDZ domain PF13855 - Leucine rich repeat
ModBase Predicted Comparative 3D Structure on Q14160-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.