Description: Homo sapiens transcription factor 3 (TCF3), transcript variant 2, mRNA. RefSeq Summary (NM_001136139): This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr19:1,609,289-1,650,286 Size: 40,998 Total Exon Count: 19 Strand: - Coding Region Position: hg19 chr19:1,611,706-1,650,247 Size: 38,542 Coding Exon Count: 18
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15923-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF385513 - JP 2014500723-A/193016: Polycomb-Associated Non-Coding RNAs. AK024806 - Homo sapiens cDNA: FLJ21153 fis, clone CAS09631, highly similar to HUMTFAA Human transcription factor (E2A) mRNA. BC005166 - Homo sapiens transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47), mRNA (cDNA clone IMAGE:3534334), partial cds. BC014680 - Homo sapiens transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47), mRNA (cDNA clone IMAGE:3864558), with apparent retained intron. BC011665 - Homo sapiens transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47), mRNA (cDNA clone IMAGE:4110737), partial cds. LP895383 - Sequence 247 from Patent EP3253886. M31523 - Human transcription factor (E2A) mRNA, complete cds. JD056660 - Sequence 37684 from Patent EP1572962. JD246087 - Sequence 227111 from Patent EP1572962. JD401418 - Sequence 382442 from Patent EP1572962. JD360579 - Sequence 341603 from Patent EP1572962. JD385632 - Sequence 366656 from Patent EP1572962. X52078 - Human transcription factor (ITF-1) mRNA, 3' end. JD124094 - Sequence 105118 from Patent EP1572962. JD214439 - Sequence 195463 from Patent EP1572962. JD237351 - Sequence 218375 from Patent EP1572962. JD417237 - Sequence 398261 from Patent EP1572962. JD226178 - Sequence 207202 from Patent EP1572962. JD036997 - Sequence 18021 from Patent EP1572962. JD536951 - Sequence 517975 from Patent EP1572962. JD204098 - Sequence 185122 from Patent EP1572962. JD426001 - Sequence 407025 from Patent EP1572962. JD398100 - Sequence 379124 from Patent EP1572962. JD390584 - Sequence 371608 from Patent EP1572962. JD090402 - Sequence 71426 from Patent EP1572962. JD376226 - Sequence 357250 from Patent EP1572962. JD551503 - Sequence 532527 from Patent EP1572962. JD528784 - Sequence 509808 from Patent EP1572962. JD503576 - Sequence 484600 from Patent EP1572962. JD077756 - Sequence 58780 from Patent EP1572962. JD395984 - Sequence 377008 from Patent EP1572962. JD205848 - Sequence 186872 from Patent EP1572962. JD519795 - Sequence 500819 from Patent EP1572962. JD317995 - Sequence 299019 from Patent EP1572962. JD368963 - Sequence 349987 from Patent EP1572962. JD365131 - Sequence 346155 from Patent EP1572962. JD065698 - Sequence 46722 from Patent EP1572962. JD388736 - Sequence 369760 from Patent EP1572962. AK310998 - Homo sapiens cDNA, FLJ18040. JD325269 - Sequence 306293 from Patent EP1572962. JD231312 - Sequence 212336 from Patent EP1572962. JD080793 - Sequence 61817 from Patent EP1572962. JD126332 - Sequence 107356 from Patent EP1572962. JD384585 - Sequence 365609 from Patent EP1572962. JD219053 - Sequence 200077 from Patent EP1572962. JD502482 - Sequence 483506 from Patent EP1572962. M31222 - Human e12 protein (E2A) mRNA, complete cds. M65214 - Human (HeLa) helix-loop-helix protein HE47 (E2A) mRNA, 3' end. JD510113 - Sequence 491137 from Patent EP1572962. BC110579 - Homo sapiens transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47), mRNA (cDNA clone MGC:129647 IMAGE:40007777), complete cds. BC110580 - Homo sapiens transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47), mRNA (cDNA clone MGC:129648 IMAGE:40007779), complete cds. M24405 - Homo sapiens (clone E12) kappa-E2-binding factor mRNA, 3' end. KF303591 - Homo sapiens cell-line K562 transcription factor 3 variant 3 (TCF3) mRNA, complete cds. KJ905326 - Synthetic construct Homo sapiens clone ccsbBroadEn_14857 TCF3-like gene, encodes complete protein. AB385055 - Synthetic construct DNA, clone: pF1KB5152, Homo sapiens TCF3 gene for transcription factor E2-alpha, complete cds, without stop codon, in Flexi system. M24404 - Homo sapiens (clone E47) kappa-E2-binding factor mRNA, partial cds. AY311345 - Homo sapiens E2A/PBX1 fusion protein (E2A/PBX1 fusion) mRNA, partial cds; alternatively spliced. EU155120 - Homo sapiens p120-E2A fusion (NOL1-TCF3 fusion) mRNA, partial sequence. JD401067 - Sequence 382091 from Patent EP1572962. MA621090 - JP 2018138019-A/193016: Polycomb-Associated Non-Coding RNAs. MK158097 - Homo sapiens isolate 25595 E2A/HLF fusion protein mRNA, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P15923 (Reactome details) participates in the following event(s):
R-HSA-448948 Phosphorylation of E proteins by p38 MAPK R-HSA-448962 Heterodimerization of E proteins with Myod R-HSA-448963 Interaction of MyoD:E protein with MEF2 R-HSA-8956568 RUNX1 binds the core TAL1 complex R-HSA-8956586 RUNX1-containing TAL1 complex binds the MYB gene enhancer R-HSA-375170 CDO in myogenesis R-HSA-525793 Myogenesis R-HSA-1266738 Developmental Biology R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8878171 Transcriptional regulation by RUNX1 R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)