Human Gene WNK1 (uc031qfk.1)
  Description: Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 4, mRNA.
RefSeq Summary (NM_001184985): This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Transcript (Including UTRs)
   Position: hg19 chr12:862,089-1,020,618 Size: 158,530 Total Exon Count: 31 Strand: +
Coding Region
   Position: hg19 chr12:862,732-1,017,958 Size: 155,227 Coding Exon Count: 31 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:862,089-1,020,618)mRNA (may differ from genome)Protein (2833 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHuman Cortex Gene ExpressionLynxMalacardsMGI
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): WNK1
CDC HuGE Published Literature: WNK1
Positive Disease Associations: Essential Hypertension
Related Studies:
  1. Essential Hypertension
    Newhouse et al (2005) Hum Mol Genet, 14, 1805-14., Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study, Human molecular genetics. 2005 Jul;14(13):1805-14. [PubMed 15888480]

-  MalaCards Disease Associations
  MalaCards Gene Search: WNK1
Diseases sorted by gene-association score: neuropathy, hereditary sensory and autonomic, type ii* (1450), pseudohypoaldosteronism, type iic* (1350), pseudohypoaldosteronism (26), paronychia (13), neuropathy (13), arthrogryposis, distal, type 3 (12), autonomic neuropathy (12), familial hypertension (12), pseudohyperkalemia, familial, 2, due to red cell leak (9), autonomic dysfunction (7), renal tubular transport disease (7), insensitivity to pain, congenital (5), hypertension, essential (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.27 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1015.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -343.50643-0.534 Picture PostScript Text
3' UTR -728.342660-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR024678 - Kinase_OSR1/WNK_CCT
IPR000719 - Prot_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12202 - Oxidative-stress-responsive kinase 1 C-terminal domain

SCOP Domains:
56112 - Protein kinase-like (PK-like)

ModBase Predicted Comparative 3D Structure on H6WZW3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details  Gene Details 
Gene SorterGene Sorter  Gene Sorter 
 RGD  WormBase 
 Protein Sequence  Protein Sequence 
 Alignment  Alignment 

-  Descriptions from all associated GenBank mRNAs
  AF061944 - Homo sapiens kinase deficient protein KDP mRNA, partial cds.
LF384181 - JP 2014500723-A/191684: Polycomb-Associated Non-Coding RNAs.
BC021121 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4653173), with apparent retained intron.
BC071959 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4651132), with apparent retained intron.
BC094862 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4650586), with apparent retained intron.
BC172444 - Synthetic construct Homo sapiens clone IMAGE:100069138, MGC:199149 WNK lysine deficient protein kinase 1 (WNK1) mRNA, encodes complete protein.
KJ903118 - Synthetic construct Homo sapiens clone ccsbBroadEn_12512 WNK1 gene, encodes complete protein.
KJ905529 - Synthetic construct Homo sapiens clone ccsbBroadEn_15140 WNK1 gene, encodes complete protein.
AJ296290 - Homo sapiens mRNA for putative protein kinase (WNK1 gene).
JQ358908 - Homo sapiens WNK lysine deficient protein kinase 1 isoform (WNK1) mRNA, complete cds, alternatively spliced.
BC141881 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:40126884), partial cds.
AB002342 - Homo sapiens mRNA for KIAA0344 gene, partial cds.
MA619758 - JP 2018138019-A/191684: Polycomb-Associated Non-Coding RNAs.
LF365544 - JP 2014500723-A/173047: Polycomb-Associated Non-Coding RNAs.
LF365542 - JP 2014500723-A/173045: Polycomb-Associated Non-Coding RNAs.
LF365541 - JP 2014500723-A/173044: Polycomb-Associated Non-Coding RNAs.
JD020646 - Sequence 1670 from Patent EP1572962.
JD036178 - Sequence 17202 from Patent EP1572962.
JD020671 - Sequence 1695 from Patent EP1572962.
JD029655 - Sequence 10679 from Patent EP1572962.
LF365540 - JP 2014500723-A/173043: Polycomb-Associated Non-Coding RNAs.
JD019614 - Sequence 638 from Patent EP1572962.
JD021269 - Sequence 2293 from Patent EP1572962.
JD030606 - Sequence 11630 from Patent EP1572962.
JD035859 - Sequence 16883 from Patent EP1572962.
JD035526 - Sequence 16550 from Patent EP1572962.
LF365538 - JP 2014500723-A/173041: Polycomb-Associated Non-Coding RNAs.
MA601121 - JP 2018138019-A/173047: Polycomb-Associated Non-Coding RNAs.
MA601119 - JP 2018138019-A/173045: Polycomb-Associated Non-Coding RNAs.
MA601118 - JP 2018138019-A/173044: Polycomb-Associated Non-Coding RNAs.
MA601117 - JP 2018138019-A/173043: Polycomb-Associated Non-Coding RNAs.
MA601115 - JP 2018138019-A/173041: Polycomb-Associated Non-Coding RNAs.
LF365530 - JP 2014500723-A/173033: Polycomb-Associated Non-Coding RNAs.
LF365526 - JP 2014500723-A/173029: Polycomb-Associated Non-Coding RNAs.
LF365525 - JP 2014500723-A/173028: Polycomb-Associated Non-Coding RNAs.
LF365523 - JP 2014500723-A/173026: Polycomb-Associated Non-Coding RNAs.
LF365522 - JP 2014500723-A/173025: Polycomb-Associated Non-Coding RNAs.
LF365521 - JP 2014500723-A/173024: Polycomb-Associated Non-Coding RNAs.
LF365520 - JP 2014500723-A/173023: Polycomb-Associated Non-Coding RNAs.
BC130467 - Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163339 IMAGE:40146498), complete cds.
BC130469 - Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163341 IMAGE:40146500), complete cds.
HQ258417 - Synthetic construct Homo sapiens clone IMAGE:100072846 Unknown protein gene, encodes complete protein.
KJ905093 - Synthetic construct Homo sapiens clone ccsbBroadEn_14487 WNK1 gene, encodes complete protein.
LF365510 - JP 2014500723-A/173013: Polycomb-Associated Non-Coding RNAs.
LF365509 - JP 2014500723-A/173012: Polycomb-Associated Non-Coding RNAs.
LF365508 - JP 2014500723-A/173011: Polycomb-Associated Non-Coding RNAs.
LF365507 - JP 2014500723-A/173010: Polycomb-Associated Non-Coding RNAs.
LF365501 - JP 2014500723-A/173004: Polycomb-Associated Non-Coding RNAs.
LF365499 - JP 2014500723-A/173002: Polycomb-Associated Non-Coding RNAs.
LF365497 - JP 2014500723-A/173000: Polycomb-Associated Non-Coding RNAs.
LF365495 - JP 2014500723-A/172998: Polycomb-Associated Non-Coding RNAs.
LF365494 - JP 2014500723-A/172997: Polycomb-Associated Non-Coding RNAs.
LF365493 - JP 2014500723-A/172996: Polycomb-Associated Non-Coding RNAs.
LF365492 - JP 2014500723-A/172995: Polycomb-Associated Non-Coding RNAs.
LF365490 - JP 2014500723-A/172993: Polycomb-Associated Non-Coding RNAs.
LF365489 - JP 2014500723-A/172992: Polycomb-Associated Non-Coding RNAs.
LF365488 - JP 2014500723-A/172991: Polycomb-Associated Non-Coding RNAs.
LF365486 - JP 2014500723-A/172989: Polycomb-Associated Non-Coding RNAs.
LF365482 - JP 2014500723-A/172985: Polycomb-Associated Non-Coding RNAs.
LF365481 - JP 2014500723-A/172984: Polycomb-Associated Non-Coding RNAs.
LF365479 - JP 2014500723-A/172982: Polycomb-Associated Non-Coding RNAs.
LF365478 - JP 2014500723-A/172981: Polycomb-Associated Non-Coding RNAs.
DQ925671 - Homo sapiens clone 2-1 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925672 - Homo sapiens clone 3B-4 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925669 - Homo sapiens clone 2A-3 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925670 - Homo sapiens clone 1B-2 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
AK128619 - Homo sapiens cDNA FLJ46778 fis, clone TRACH3026949.
BC013629 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:3445410), partial cds.
LF365468 - JP 2014500723-A/172971: Polycomb-Associated Non-Coding RNAs.
LF365466 - JP 2014500723-A/172969: Polycomb-Associated Non-Coding RNAs.
LF365465 - JP 2014500723-A/172968: Polycomb-Associated Non-Coding RNAs.
BC035146 - Homo sapiens cDNA clone IMAGE:5264735.
BC044600 - Homo sapiens cDNA clone IMAGE:4814776.
LF365463 - JP 2014500723-A/172966: Polycomb-Associated Non-Coding RNAs.
LF365462 - JP 2014500723-A/172965: Polycomb-Associated Non-Coding RNAs.
LF365461 - JP 2014500723-A/172964: Polycomb-Associated Non-Coding RNAs.
DQ580784 - Homo sapiens piRNA piR-48896, complete sequence.
LF365460 - JP 2014500723-A/172963: Polycomb-Associated Non-Coding RNAs.
LF365458 - JP 2014500723-A/172961: Polycomb-Associated Non-Coding RNAs.
LF365457 - JP 2014500723-A/172960: Polycomb-Associated Non-Coding RNAs.
MA601107 - JP 2018138019-A/173033: Polycomb-Associated Non-Coding RNAs.
MA601103 - JP 2018138019-A/173029: Polycomb-Associated Non-Coding RNAs.
MA601102 - JP 2018138019-A/173028: Polycomb-Associated Non-Coding RNAs.
MA601100 - JP 2018138019-A/173026: Polycomb-Associated Non-Coding RNAs.
MA601099 - JP 2018138019-A/173025: Polycomb-Associated Non-Coding RNAs.
MA601098 - JP 2018138019-A/173024: Polycomb-Associated Non-Coding RNAs.
MA601097 - JP 2018138019-A/173023: Polycomb-Associated Non-Coding RNAs.
MA601087 - JP 2018138019-A/173013: Polycomb-Associated Non-Coding RNAs.
MA601086 - JP 2018138019-A/173012: Polycomb-Associated Non-Coding RNAs.
MA601085 - JP 2018138019-A/173011: Polycomb-Associated Non-Coding RNAs.
MA601084 - JP 2018138019-A/173010: Polycomb-Associated Non-Coding RNAs.
MA601078 - JP 2018138019-A/173004: Polycomb-Associated Non-Coding RNAs.
MA601076 - JP 2018138019-A/173002: Polycomb-Associated Non-Coding RNAs.
MA601074 - JP 2018138019-A/173000: Polycomb-Associated Non-Coding RNAs.
MA601072 - JP 2018138019-A/172998: Polycomb-Associated Non-Coding RNAs.
MA601071 - JP 2018138019-A/172997: Polycomb-Associated Non-Coding RNAs.
MA601070 - JP 2018138019-A/172996: Polycomb-Associated Non-Coding RNAs.
MA601069 - JP 2018138019-A/172995: Polycomb-Associated Non-Coding RNAs.
MA601067 - JP 2018138019-A/172993: Polycomb-Associated Non-Coding RNAs.
MA601066 - JP 2018138019-A/172992: Polycomb-Associated Non-Coding RNAs.
MA601065 - JP 2018138019-A/172991: Polycomb-Associated Non-Coding RNAs.
MA601063 - JP 2018138019-A/172989: Polycomb-Associated Non-Coding RNAs.
MA601059 - JP 2018138019-A/172985: Polycomb-Associated Non-Coding RNAs.
MA601058 - JP 2018138019-A/172984: Polycomb-Associated Non-Coding RNAs.
MA601056 - JP 2018138019-A/172982: Polycomb-Associated Non-Coding RNAs.
MA601055 - JP 2018138019-A/172981: Polycomb-Associated Non-Coding RNAs.
MA601045 - JP 2018138019-A/172971: Polycomb-Associated Non-Coding RNAs.
MA601043 - JP 2018138019-A/172969: Polycomb-Associated Non-Coding RNAs.
MA601042 - JP 2018138019-A/172968: Polycomb-Associated Non-Coding RNAs.
MA601040 - JP 2018138019-A/172966: Polycomb-Associated Non-Coding RNAs.
MA601039 - JP 2018138019-A/172965: Polycomb-Associated Non-Coding RNAs.
MA601038 - JP 2018138019-A/172964: Polycomb-Associated Non-Coding RNAs.
MA601037 - JP 2018138019-A/172963: Polycomb-Associated Non-Coding RNAs.
MA601035 - JP 2018138019-A/172961: Polycomb-Associated Non-Coding RNAs.
MA601034 - JP 2018138019-A/172960: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: H6WZW3, H6WZW3_HUMAN, JQ358908, NM_001184985, NP_001171914, uc021qss.1
UCSC ID: uc031qfk.1
RefSeq Accession: NM_001184985
Protein: H6WZW3

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene WNK1:
hsan2 (Hereditary Sensory and Autonomic Neuropathy Type II)
pha2 (Pseudohypoaldosteronism Type II)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: JQ358908.1
exon count: 31CDS single in 3' UTR: no RNA size: 8502
ORF size: 8502CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 17006.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.