Human Gene WNK1 (uc031qfk.1)
Description: Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 4, mRNA.
RefSeq Summary (NM_001184985): This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Transcript (Including UTRs)
Position: hg19 chr12:862,089-1,020,618 Size: 158,530 Total Exon Count: 31 Strand: +
Coding Region
Position: hg19 chr12:862,732-1,017,958 Size: 155,227 Coding Exon Count: 31
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): WNK1
CDC HuGE Published Literature: WNK1
Positive Disease Associations: Essential Hypertension
Related Studies: Essential Hypertension Newhouse et al (2005) Hum Mol Genet, 14, 1805-14., Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study, Human molecular genetics. 2005 Jul;14(13):1805-14.
[PubMed 15888480 ]
MalaCards Disease Associations
MalaCards Gene Search: WNK1
Diseases sorted by gene-association score: neuropathy, hereditary sensory and autonomic, type ii * (1450), pseudohypoaldosteronism, type iic * (1350), pseudohypoaldosteronism (26), paronychia (13), neuropathy (13), arthrogryposis, distal, type 3 (12), autonomic neuropathy (12), familial hypertension (12), pseudohyperkalemia, familial, 2, due to red cell leak (9), autonomic dysfunction (7), renal tubular transport disease (7), insensitivity to pain, congenital (5), hypertension, essential (2)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011009 - Kinase-like_dom
IPR024678 - Kinase_OSR1/WNK_CCT
IPR000719 - Prot_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS
Pfam Domains: PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF12202 - Oxidative-stress-responsive kinase 1 C-terminal domain
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on H6WZW3
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AF061944 - Homo sapiens kinase deficient protein KDP mRNA, partial cds.LF384181 - JP 2014500723-A/191684: Polycomb-Associated Non-Coding RNAs.BC021121 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4653173), with apparent retained intron.BC071959 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4651132), with apparent retained intron.BC094862 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4650586), with apparent retained intron.BC172444 - Synthetic construct Homo sapiens clone IMAGE:100069138, MGC:199149 WNK lysine deficient protein kinase 1 (WNK1) mRNA, encodes complete protein.KJ903118 - Synthetic construct Homo sapiens clone ccsbBroadEn_12512 WNK1 gene, encodes complete protein.KJ905529 - Synthetic construct Homo sapiens clone ccsbBroadEn_15140 WNK1 gene, encodes complete protein.AJ296290 - Homo sapiens mRNA for putative protein kinase (WNK1 gene).JQ358908 - Homo sapiens WNK lysine deficient protein kinase 1 isoform (WNK1) mRNA, complete cds, alternatively spliced.BC141881 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:40126884), partial cds.AB002342 - Homo sapiens mRNA for KIAA0344 gene, partial cds.MA619758 - JP 2018138019-A/191684: Polycomb-Associated Non-Coding RNAs.LF365544 - JP 2014500723-A/173047: Polycomb-Associated Non-Coding RNAs.LF365542 - JP 2014500723-A/173045: Polycomb-Associated Non-Coding RNAs.LF365541 - JP 2014500723-A/173044: Polycomb-Associated Non-Coding RNAs.JD020646 - Sequence 1670 from Patent EP1572962.JD036178 - Sequence 17202 from Patent EP1572962.JD020671 - Sequence 1695 from Patent EP1572962.JD029655 - Sequence 10679 from Patent EP1572962.LF365540 - JP 2014500723-A/173043: Polycomb-Associated Non-Coding RNAs.JD019614 - Sequence 638 from Patent EP1572962.JD021269 - Sequence 2293 from Patent EP1572962.JD030606 - Sequence 11630 from Patent EP1572962.JD035859 - Sequence 16883 from Patent EP1572962.JD035526 - Sequence 16550 from Patent EP1572962.LF365538 - JP 2014500723-A/173041: Polycomb-Associated Non-Coding RNAs.MA601121 - JP 2018138019-A/173047: Polycomb-Associated Non-Coding RNAs.MA601119 - JP 2018138019-A/173045: Polycomb-Associated Non-Coding RNAs.MA601118 - JP 2018138019-A/173044: Polycomb-Associated Non-Coding RNAs.MA601117 - JP 2018138019-A/173043: Polycomb-Associated Non-Coding RNAs.MA601115 - JP 2018138019-A/173041: Polycomb-Associated Non-Coding RNAs.LF365530 - JP 2014500723-A/173033: Polycomb-Associated Non-Coding RNAs.LF365526 - JP 2014500723-A/173029: Polycomb-Associated Non-Coding RNAs.LF365525 - JP 2014500723-A/173028: Polycomb-Associated Non-Coding RNAs.LF365523 - JP 2014500723-A/173026: Polycomb-Associated Non-Coding RNAs.LF365522 - JP 2014500723-A/173025: Polycomb-Associated Non-Coding RNAs.LF365521 - JP 2014500723-A/173024: Polycomb-Associated Non-Coding RNAs.LF365520 - JP 2014500723-A/173023: Polycomb-Associated Non-Coding RNAs.BC130467 - Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163339 IMAGE:40146498), complete cds.BC130469 - Homo sapiens hereditary sensory neuropathy, type II, mRNA (cDNA clone MGC:163341 IMAGE:40146500), complete cds.HQ258417 - Synthetic construct Homo sapiens clone IMAGE:100072846 Unknown protein gene, encodes complete protein.KJ905093 - Synthetic construct Homo sapiens clone ccsbBroadEn_14487 WNK1 gene, encodes complete protein.LF365510 - JP 2014500723-A/173013: Polycomb-Associated Non-Coding RNAs.LF365509 - JP 2014500723-A/173012: Polycomb-Associated Non-Coding RNAs.LF365508 - JP 2014500723-A/173011: Polycomb-Associated Non-Coding RNAs.LF365507 - JP 2014500723-A/173010: Polycomb-Associated Non-Coding RNAs.LF365501 - JP 2014500723-A/173004: Polycomb-Associated Non-Coding RNAs.LF365499 - JP 2014500723-A/173002: Polycomb-Associated Non-Coding RNAs.LF365497 - JP 2014500723-A/173000: Polycomb-Associated Non-Coding RNAs.LF365495 - JP 2014500723-A/172998: Polycomb-Associated Non-Coding RNAs.LF365494 - JP 2014500723-A/172997: Polycomb-Associated Non-Coding RNAs.LF365493 - JP 2014500723-A/172996: Polycomb-Associated Non-Coding RNAs.LF365492 - JP 2014500723-A/172995: Polycomb-Associated Non-Coding RNAs.LF365490 - JP 2014500723-A/172993: Polycomb-Associated Non-Coding RNAs.LF365489 - JP 2014500723-A/172992: Polycomb-Associated Non-Coding RNAs.LF365488 - JP 2014500723-A/172991: Polycomb-Associated Non-Coding RNAs.LF365486 - JP 2014500723-A/172989: Polycomb-Associated Non-Coding RNAs.LF365482 - JP 2014500723-A/172985: Polycomb-Associated Non-Coding RNAs.LF365481 - JP 2014500723-A/172984: Polycomb-Associated Non-Coding RNAs.LF365479 - JP 2014500723-A/172982: Polycomb-Associated Non-Coding RNAs.LF365478 - JP 2014500723-A/172981: Polycomb-Associated Non-Coding RNAs.DQ925671 - Homo sapiens clone 2-1 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.DQ925672 - Homo sapiens clone 3B-4 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.DQ925669 - Homo sapiens clone 2A-3 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.DQ925670 - Homo sapiens clone 1B-2 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.AK128619 - Homo sapiens cDNA FLJ46778 fis, clone TRACH3026949.BC013629 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:3445410), partial cds.LF365468 - JP 2014500723-A/172971: Polycomb-Associated Non-Coding RNAs.LF365466 - JP 2014500723-A/172969: Polycomb-Associated Non-Coding RNAs.LF365465 - JP 2014500723-A/172968: Polycomb-Associated Non-Coding RNAs.BC035146 - Homo sapiens cDNA clone IMAGE:5264735.BC044600 - Homo sapiens cDNA clone IMAGE:4814776.LF365463 - JP 2014500723-A/172966: Polycomb-Associated Non-Coding RNAs.LF365462 - JP 2014500723-A/172965: Polycomb-Associated Non-Coding RNAs.LF365461 - JP 2014500723-A/172964: Polycomb-Associated Non-Coding RNAs.DQ580784 - Homo sapiens piRNA piR-48896, complete sequence.LF365460 - JP 2014500723-A/172963: Polycomb-Associated Non-Coding RNAs.LF365458 - JP 2014500723-A/172961: Polycomb-Associated Non-Coding RNAs.LF365457 - JP 2014500723-A/172960: Polycomb-Associated Non-Coding RNAs.MA601107 - JP 2018138019-A/173033: Polycomb-Associated Non-Coding RNAs.MA601103 - JP 2018138019-A/173029: Polycomb-Associated Non-Coding RNAs.MA601102 - JP 2018138019-A/173028: Polycomb-Associated Non-Coding RNAs.MA601100 - JP 2018138019-A/173026: Polycomb-Associated Non-Coding RNAs.MA601099 - JP 2018138019-A/173025: Polycomb-Associated Non-Coding RNAs.MA601098 - JP 2018138019-A/173024: Polycomb-Associated Non-Coding RNAs.MA601097 - JP 2018138019-A/173023: Polycomb-Associated Non-Coding RNAs.MA601087 - JP 2018138019-A/173013: Polycomb-Associated Non-Coding RNAs.MA601086 - JP 2018138019-A/173012: Polycomb-Associated Non-Coding RNAs.MA601085 - JP 2018138019-A/173011: Polycomb-Associated Non-Coding RNAs.MA601084 - JP 2018138019-A/173010: Polycomb-Associated Non-Coding RNAs.MA601078 - JP 2018138019-A/173004: Polycomb-Associated Non-Coding RNAs.MA601076 - JP 2018138019-A/173002: Polycomb-Associated Non-Coding RNAs.MA601074 - JP 2018138019-A/173000: Polycomb-Associated Non-Coding RNAs.MA601072 - JP 2018138019-A/172998: Polycomb-Associated Non-Coding RNAs.MA601071 - JP 2018138019-A/172997: Polycomb-Associated Non-Coding RNAs.MA601070 - JP 2018138019-A/172996: Polycomb-Associated Non-Coding RNAs.MA601069 - JP 2018138019-A/172995: Polycomb-Associated Non-Coding RNAs.MA601067 - JP 2018138019-A/172993: Polycomb-Associated Non-Coding RNAs.MA601066 - JP 2018138019-A/172992: Polycomb-Associated Non-Coding RNAs.MA601065 - JP 2018138019-A/172991: Polycomb-Associated Non-Coding RNAs.MA601063 - JP 2018138019-A/172989: Polycomb-Associated Non-Coding RNAs.MA601059 - JP 2018138019-A/172985: Polycomb-Associated Non-Coding RNAs.MA601058 - JP 2018138019-A/172984: Polycomb-Associated Non-Coding RNAs.MA601056 - JP 2018138019-A/172982: Polycomb-Associated Non-Coding RNAs.MA601055 - JP 2018138019-A/172981: Polycomb-Associated Non-Coding RNAs.MA601045 - JP 2018138019-A/172971: Polycomb-Associated Non-Coding RNAs.MA601043 - JP 2018138019-A/172969: Polycomb-Associated Non-Coding RNAs.MA601042 - JP 2018138019-A/172968: Polycomb-Associated Non-Coding RNAs.MA601040 - JP 2018138019-A/172966: Polycomb-Associated Non-Coding RNAs.MA601039 - JP 2018138019-A/172965: Polycomb-Associated Non-Coding RNAs.MA601038 - JP 2018138019-A/172964: Polycomb-Associated Non-Coding RNAs.MA601037 - JP 2018138019-A/172963: Polycomb-Associated Non-Coding RNAs.MA601035 - JP 2018138019-A/172961: Polycomb-Associated Non-Coding RNAs.MA601034 - JP 2018138019-A/172960: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: H6WZW3, H6WZW3_HUMAN, JQ358908, NM_001184985, NP_001171914, uc021qss.1UCSC ID: uc031qfk.1RefSeq Accession: NM_001184985
Protein: H6WZW3
GeneReviews for This Gene
GeneReviews article(s) related to gene WNK1:hsan2 (Hereditary Sensory and Autonomic Neuropathy Type II)pha2 (Pseudohypoaldosteronism Type II)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
JQ358908.1
exon count:
31 CDS single in 3' UTR:
no
RNA size:
8502
ORF size:
8502 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
17006.50 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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