Human Gene IGFALS (ENST00000215539.4) from GENCODE V44
Description: Homo sapiens insulin like growth factor binding protein acid labile subunit (IGFALS), transcript variant 2, mRNA. (from RefSeq NM_004970) RefSeq Summary (NM_004970): The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]. Gencode Transcript: ENST00000215539.4 Gencode Gene: ENSG00000099769.6 Transcript (Including UTRs) Position: hg38 chr16:1,790,413-1,793,705 Size: 3,293 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr16:1,790,600-1,793,652 Size: 3,053 Coding Exon Count: 2
ID:ALS_HUMAN DESCRIPTION: RecName: Full=Insulin-like growth factor-binding protein complex acid labile subunit; Short=ALS; Flags: Precursor; FUNCTION: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. SUBUNIT: Forms a ternary complex of about 140 to 150 kDa with IGF- I or IGF-II and IGFBP-3. SUBCELLULAR LOCATION: Secreted, extracellular space. TISSUE SPECIFICITY: Plasma. SIMILARITY: Contains 19 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 LRRNT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35858
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
