ID:ABCA8_HUMAN DESCRIPTION: RecName: Full=ATP-binding cassette sub-family A member 8; FUNCTION: ATP-dependent lipophilic drug transporter. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30.4 uM for estradiol-beta-glucuronide; KM=0.1 uM for LTC4; KM=10.3 uM for taurochlorate; KM=5.0 uM for PAH; KM=0.5 uM for estrone sulfate; KM=0.4 uM for ochratoxin A; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Probable). TISSUE SPECIFICITY: Widely expressed with higher expression in heart, skeletal muscle and liver. SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family. SIMILARITY: Contains 2 ABC transporter domains. SEQUENCE CAUTION: Sequence=BAA74845.2; Type=Erroneous initiation; WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O94911";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O94911
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB020629 - Homo sapiens KIAA0822 mRNA for KIAA0822 protein. AK304360 - Homo sapiens cDNA FLJ61077 complete cds, highly similar to Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8), mRNA. BC130280 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone MGC:163152 IMAGE:40146311), complete cds. BC143972 - Homo sapiens cDNA clone IMAGE:9052490, containing frame-shift errors. BC143971 - Homo sapiens cDNA clone IMAGE:9052489, containing frame-shift errors. AK304286 - Homo sapiens cDNA FLJ50363 complete cds, highly similar to Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8), mRNA. AK295876 - Homo sapiens cDNA FLJ56986 partial cds, highly similar to Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8), mRNA. BC037309 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone IMAGE:5262251), complete cds. BC047765 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone IMAGE:5761384), complete cds. BC094689 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone IMAGE:30374415), complete cds. BC010392 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone IMAGE:4249503), with apparent retained intron. BC024003 - Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 8, mRNA (cDNA clone IMAGE:4821839), complete cds. JD061588 - Sequence 42612 from Patent EP1572962. JD317557 - Sequence 298581 from Patent EP1572962. JD513010 - Sequence 494034 from Patent EP1572962. JD132545 - Sequence 113569 from Patent EP1572962. JD254236 - Sequence 235260 from Patent EP1572962. JD410677 - Sequence 391701 from Patent EP1572962. JD058650 - Sequence 39674 from Patent EP1572962. JD289343 - Sequence 270367 from Patent EP1572962. JD283411 - Sequence 264435 from Patent EP1572962. JD224190 - Sequence 205214 from Patent EP1572962. JD464681 - Sequence 445705 from Patent EP1572962. AB527097 - Synthetic construct DNA, clone: pF1KA0822, Homo sapiens ABCA8 gene for ATP-binding cassette, sub-family A (ABC1), member 8, without stop codon, in Flexi system. JD444291 - Sequence 425315 from Patent EP1572962. JD396977 - Sequence 378001 from Patent EP1572962. JD305445 - Sequence 286469 from Patent EP1572962. AK090894 - Homo sapiens cDNA FLJ33575 fis, clone BRAMY2011216. CU690496 - Synthetic construct Homo sapiens gateway clone IMAGE:100022702 5' read ABCA8 mRNA. KJ902094 - Synthetic construct Homo sapiens clone ccsbBroadEn_11488 ABCA8 gene, encodes complete protein. JD347818 - Sequence 328842 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa02010 - ABC transporters
Reactome (by CSHL, EBI, and GO)
Protein O94911 (Reactome details) participates in the following event(s):
R-HSA-1467457 ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region R-HSA-382556 ABC-family proteins mediated transport R-HSA-382551 Transport of small molecules
Sequence and Links to Tools and Databases 
Microarray Expression Data 
