Human Gene ACAP2 (ENST00000326793.11) from GENCODE V50

Description: ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 (from RefSeq NM_012287.6)
Gencode Transcript: ENST00000326793.11
Gencode Gene: ENSG00000114331.18
Transcript (Including UTRs)
Position: hg38 chr3:195,274,745-195,443,020 Size: 168,276 Total Exon Count: 23 Strand: -
Coding Region
Position: hg38 chr3:195,279,328-195,442,847 Size: 163,520 Coding Exon Count: 23

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:195,274,745-195,443,020)			mRNA (may differ from genome)		Protein (778 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ACAP2_HUMAN DESCRIPTION: RecName: Full=Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; AltName: Full=Centaurin-beta-2; Short=Cnt-b2; FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). ENZYME REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. TISSUE SPECIFICITY: Widely expressed. Highest level in lung. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 3 ANK repeats. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAA05064.2; Type=Erroneous initiation; Sequence=CAB41450.1; Type=Frameshift; Positions=98, 106, 111;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene C495817 CC-8490 D002737 Chloroprene D003010 Clorgyline D019327 Copper Sulfate D016572 Cyclosporine D004052 Diethylnitrosamine D011078 Polychlorinated Biphenyls more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 12.79 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 322.52 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-80.80	173	-0.467	Picture	PostScript	Text
3' UTR	-1084.50	4583	-0.237	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom
IPR001164 - ArfGAP
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00023 - Ankyrin repeat
PF01412 - Putative GTPase activating protein for Arf
PF00169 - PH domain

ModBase Predicted Comparative 3D Structure on Q15057


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD
Protein Sequence	Protein Sequence
Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005096 GTPase activator activity GO:0046872 metal ion binding Biological Process: GO:0036010 protein localization to endosome GO:0043547 positive regulation of GTPase activity GO:1990090 cellular response to nerve growth factor stimulus Cellular Component: GO:0005768 endosome GO:0010008 endosome membrane GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	D26069 - Homo sapiens KIAA0041 mRNA. BC060767 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 2, mRNA (cDNA clone MGC:71512 IMAGE:30343546), complete cds. LP895477 - Sequence 341 from Patent EP3253886. AJ238248 - Homo sapiens mRNA for centaurin beta2. AK290369 - Homo sapiens cDNA FLJ75053 complete cds, highly similar to Homo sapiens centaurin, beta 2 (CENTB2), mRNA. AB385269 - Synthetic construct DNA, clone: pF1KA0041, Homo sapiens CENTB2 gene for centaurin-beta 2, complete cds, without stop codon, in Flexi system. AK222635 - Homo sapiens mRNA, centaurin, beta 2 variant, clone: CBL03533. BC047579 - Homo sapiens centaurin, beta 2, mRNA (cDNA clone IMAGE:4818240). BC017120 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 2, mRNA (cDNA clone IMAGE:3919558), with apparent retained intron. BC014843 - Homo sapiens centaurin, beta 2, mRNA (cDNA clone IMAGE:3048719), partial cds. BC031005 - Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains 2, mRNA (cDNA clone IMAGE:4287344), partial cds. JD314232 - Sequence 295256 from Patent EP1572962. JD555495 - Sequence 536519 from Patent EP1572962. JD245243 - Sequence 226267 from Patent EP1572962. JD442423 - Sequence 423447 from Patent EP1572962. JD091114 - Sequence 72138 from Patent EP1572962. JD545510 - Sequence 526534 from Patent EP1572962. JD129313 - Sequence 110337 from Patent EP1572962.

Biochemical and Signaling Pathways


	KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis

Other Names for This Gene


	Alternate Gene Symbols: A8K2V4, ACAP2_HUMAN, CENTB2, ENST00000326793.1, ENST00000326793.10, ENST00000326793.2, ENST00000326793.3, ENST00000326793.4, ENST00000326793.5, ENST00000326793.6, ENST00000326793.7, ENST00000326793.8, ENST00000326793.9, KIAA0041, NM_012287, Q15057, Q8N5Z8, Q9UQR3, uc003fun.1, uc003fun.2, uc003fun.3, uc003fun.4, uc003fun.5, uc003fun.6 UCSC ID: ENST00000326793.11 RefSeq Accession: NM_012287.6 Protein: Q15057 (aka ACAP2_HUMAN) CCDS: CCDS33924.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips