ID:ACBG1_HUMAN DESCRIPTION: RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1; EC=6.2.1.3; AltName: Full=Acyl-CoA synthetase bubblegum family member 1; Short=hBG1; Short=hsBG; Short=hsBGM; AltName: Full=Lipidosin; FUNCTION: Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. CATALYTIC ACTIVITY: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity). TISSUE SPECIFICITY: Expressed primarily in brain. Expressed at lower level in testis and adrenal gland. Present in all regions of brain except pituitary. SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily. SEQUENCE CAUTION: Sequence=BAA31606.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96GR2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000038 very long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0008152 metabolic process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0042552 myelination GO:0051384 response to glucocorticoid
Sequence and Links to Tools and Databases 
Microarray Expression Data 
