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Human Gene ACTL7A (ENST00000333999.5) from GENCODE V50
  Description: actin like 7A (from RefSeq NM_006687.4)
Gencode Transcript: ENST00000333999.5
Gencode Gene: ENSG00000187003.7
Transcript (Including UTRs)
   Position: hg38 chr9:108,862,266-108,863,756 Size: 1,491 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg38 chr9:108,862,323-108,863,630 Size: 1,308 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: ACL7A_HUMAN
DESCRIPTION: RecName: Full=Actin-like protein 7A; AltName: Full=Actin-like-7-alpha;
SUBUNIT: Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Golgi apparatus (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). Note=Detected at the Golgi apparatus during acrosome biogenesis. Detected at the subacrosomal layer in round spermatids. Detected in sperm head and tail (By similarity).
TISSUE SPECIFICITY: Strongly expressed in testis. Also expressed in other tissues.
SIMILARITY: Belongs to the actin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ACTL7A
Diseases sorted by gene-association score: hypertensive nephropathy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 255.06 RPKM in Testis
Total median expression: 255.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.8057-0.242 Picture PostScript Text
3' UTR -46.50126-0.369 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004000 - Actin-like

Pfam Domains:
PF00022 - Actin

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2XQN - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9Y615
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding

Biological Process:
GO:0007010 cytoskeleton organization

Cellular Component:
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0031514 motile cilium
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  BC014610 - Homo sapiens actin-like 7A, mRNA (cDNA clone MGC:26977 IMAGE:4825363), complete cds.
AK314981 - Homo sapiens cDNA, FLJ95897, Homo sapiens actin-like 7A (ACTL7A), mRNA.
HM005543 - Homo sapiens clone HTL-S-3 testicular secretory protein Li 3 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ACL7A_HUMAN, B2RC83, ENST00000333999.1, ENST00000333999.2, ENST00000333999.3, ENST00000333999.4, NM_006687, Q5JSV0, Q9Y615, uc004bdj.1, uc004bdj.2, uc004bdj.3, uc004bdj.4
UCSC ID: ENST00000333999.5
RefSeq Accession: NM_006687.4
Protein: Q9Y615 (aka ACL7A_HUMAN or AL7A_HUMAN)
CCDS: CCDS6772.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.