Human Gene ADGRB2 (ENST00000398556.7)
  Description: Contains 1 GPS domain. (from UniProt A2A3C6)
RefSeq Summary (NM_001364857): This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000398556.7
Gencode Gene: ENSG00000121753.12
Transcript (Including UTRs)
   Position: hg38 chr1:31,727,117-31,759,423 Size: 32,307 Total Exon Count: 29 Strand: -
Coding Region
   Position: hg38 chr1:31,727,420-31,759,350 Size: 31,931 Coding Exon Count: 29 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:31,727,117-31,759,423)mRNA (may differ from genome)Protein (1500 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Brain-specific angiogenesis inhibitor 2;
SIMILARITY: Contains 1 GPS domain.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 57.79 RPKM in Brain - Cortex
Total median expression: 417.76 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.4073-0.238 Picture PostScript Text
3' UTR -132.00303-0.436 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022624 - DUF3497
IPR017981 - GPCR_2-like
IPR008077 - GPCR_2_brain-spec_angio_inhib
IPR001879 - GPCR_2_extracellular_dom
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom
IPR000884 - Thrombospondin_1_rpt

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF12003 - n/a
PF01825 - GPCR proteolysis site, GPS, motif
PF02793 - Hormone receptor domain
PF00090 - Thrombospondin type 1 domain

ModBase Predicted Comparative 3D Structure on A2A3C6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0016525 negative regulation of angiogenesis

Cellular Component:
GO:0005813 centrosome
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC014780 - Homo sapiens brain-specific angiogenesis inhibitor 2, mRNA (cDNA clone IMAGE:4154610), with apparent retained intron.
BC009035 - Homo sapiens, Similar to brain-specific angiogenesis inhibitor 2, clone IMAGE:4155920, mRNA, partial cds.
AK123392 - Homo sapiens cDNA FLJ41398 fis, clone BRCOC2019896, highly similar to Homo sapiens brain-specific angiogenesis inhibitor 2 (BAI2).
AB005298 - Homo sapiens BAI 2 mRNA, complete cds.
JD162918 - Sequence 143942 from Patent EP1572962.
JD468107 - Sequence 449131 from Patent EP1572962.
BC136533 - Homo sapiens brain-specific angiogenesis inhibitor 2, mRNA (cDNA clone MGC:168146 IMAGE:9020523), complete cds.
AK294361 - Homo sapiens cDNA FLJ55343 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
JD139034 - Sequence 120058 from Patent EP1572962.
AK296502 - Homo sapiens cDNA FLJ53350 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
JD442632 - Sequence 423656 from Patent EP1572962.
JD296825 - Sequence 277849 from Patent EP1572962.
AB384403 - Synthetic construct DNA, clone: pF1KSDB1489, Homo sapiens BAI2 gene for brain-specific angiogenesis inhibitor 2 precursor, complete cds, without stop codon, in Flexi system.
BC053513 - Homo sapiens cDNA clone IMAGE:6598864, **** WARNING: chimeric clone ****.
AK294999 - Homo sapiens cDNA FLJ52539 complete cds, highly similar to Brain-specific angiogenesis inhibitor 2 precursor.
AK307805 - Homo sapiens cDNA, FLJ97753.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A3C6, A2A3C6_HUMAN, AB005298, BAI2, ENST00000398556.1, ENST00000398556.2, ENST00000398556.3, ENST00000398556.4, ENST00000398556.5, ENST00000398556.6, RP11-73M7.7-006, uc010ogn.1, uc010ogn.2, uc010ogn.3
UCSC ID: ENST00000398556.7
RefSeq Accession: NM_001364857
Protein: A2A3C6 CCDS: CCDS72746.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.