Human Gene ADM2 (ENST00000395737.2) from GENCODE V50

Description: adrenomedullin 2, transcript variant 2 (from RefSeq NM_001253845.2)
Gencode Transcript: ENST00000395737.2
Gencode Gene: ENSG00000128165.10
Transcript (Including UTRs)
Position: hg38 chr22:50,481,543-50,486,437 Size: 4,895 Total Exon Count: 3 Strand: +
Coding Region
Position: hg38 chr22:50,481,848-50,482,903 Size: 1,056 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:50,481,543-50,486,437)			mRNA (may differ from genome)		Protein (148 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ADM2_HUMAN DESCRIPTION: RecName: Full=ADM2; AltName: Full=Intermedin; Contains: RecName: Full=Adrenomedullin-2; Short=AM2; AltName: Full=Intermedin-long; Short=IMDL; Contains: RecName: Full=Intermedin-short; Short=IMDS; Flags: Precursor; FUNCTION: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary. SIMILARITY: Belongs to the adrenomedullin family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D002762 Cholecalciferol D004054 Diethylstilbestrol D004958 Estradiol D009538 Nicotine D009569 Nitric Oxide D010100 Oxygen C411007 PKC412 C505646 VULM 1457

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.47 RPKM in Thyroid Total median expression: 37.02 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-81.60	232	-0.352	Picture	PostScript	Text
3' UTR	-1521.50	3534	-0.431	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR021116 - Procalcitonin/adrenomedullin

Pfam Domains:
PF00214 - Calcitonin / CGRP / IAPP family

ModBase Predicted Comparative 3D Structure on Q7Z4H4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD
Protein Sequence	Protein Sequence
Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005179 hormone activity GO:0044877 macromolecular complex binding Biological Process: GO:0001525 angiogenesis GO:0006468 protein phosphorylation GO:0007186 G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007586 digestion GO:0007631 feeding behavior GO:0010469 regulation of receptor activity GO:0010628 positive regulation of gene expression GO:0045766 positive regulation of angiogenesis GO:0045776 negative regulation of blood pressure Cellular Component: GO:0005576 extracellular region GO:0005622 intracellular

Descriptions from all associated GenBank mRNAs


	AK024788 - Homo sapiens cDNA: FLJ21135 fis, clone CAS07262. AK225097 - Homo sapiens mRNA for adrenomedullin 2 precusor variant, clone: CAS07262. JD476160 - Sequence 457184 from Patent EP1572962. JD118694 - Sequence 99718 from Patent EP1572962. AB236970 - Homo sapiens ADM2 mRNA for adrenomedullin 2, complete cds. AK090635 - Homo sapiens cDNA FLJ33316 fis, clone BNGH42007366. JD397684 - Sequence 378708 from Patent EP1572962. BC141534 - Synthetic construct Homo sapiens clone IMAGE:100014523, MGC:175301 adrenomedullin 2 (ADM2) mRNA, encodes complete protein. BC146569 - Synthetic construct Homo sapiens clone IMAGE:100014799, MGC:180131 adrenomedullin 2 (ADM2) mRNA, encodes complete protein. AB463404 - Synthetic construct DNA, clone: pF1KB7250, Homo sapiens ADM2 gene for adrenomedullin 2, without stop codon, in Flexi system. AB121034 - Homo sapiens ADM2 mRNA for adrenomedullin 2, complete cds. AF529213 - Homo sapiens intermedin precursor, mRNA, complete cds. JD221060 - Sequence 202084 from Patent EP1572962. JD084587 - Sequence 65611 from Patent EP1572962. JD519811 - Sequence 500835 from Patent EP1572962. JD393246 - Sequence 374270 from Patent EP1572962. JD159803 - Sequence 140827 from Patent EP1572962. JD543535 - Sequence 524559 from Patent EP1572962. JD370493 - Sequence 351517 from Patent EP1572962. JD311024 - Sequence 292048 from Patent EP1572962. CR456479 - Homo sapiens dJ579N16.4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ579N16.4). CU013317 - Homo sapiens ADM2, mRNA (cDNA clone IMAGE:100000095), complete cds, without stop codon, in Gateway system. CU013029 - Homo sapiens ADM2, mRNA (cDNA clone IMAGE:100000191), complete cds, with stop codon, in Gateway system. JD478762 - Sequence 459786 from Patent EP1572962. JD371810 - Sequence 352834 from Patent EP1572962. JD056128 - Sequence 37152 from Patent EP1572962. JD086036 - Sequence 67060 from Patent EP1572962. JD280712 - Sequence 261736 from Patent EP1572962. JD209544 - Sequence 190568 from Patent EP1572962. JD278958 - Sequence 259982 from Patent EP1572962. JD221526 - Sequence 202550 from Patent EP1572962. JD318076 - Sequence 299100 from Patent EP1572962. JD186716 - Sequence 167740 from Patent EP1572962. JD318194 - Sequence 299218 from Patent EP1572962. JD478156 - Sequence 459180 from Patent EP1572962. JD122421 - Sequence 103445 from Patent EP1572962. JD374203 - Sequence 355227 from Patent EP1572962. JD043661 - Sequence 24685 from Patent EP1572962. AK092640 - Homo sapiens cDNA FLJ35321 fis, clone PROST2012088. JD487832 - Sequence 468856 from Patent EP1572962. JD391176 - Sequence 372200 from Patent EP1572962. JD075821 - Sequence 56845 from Patent EP1572962. JD074265 - Sequence 55289 from Patent EP1572962. JD215531 - Sequence 196555 from Patent EP1572962. JD436657 - Sequence 417681 from Patent EP1572962. JD044903 - Sequence 25927 from Patent EP1572962. JD369101 - Sequence 350125 from Patent EP1572962. JD051385 - Sequence 32409 from Patent EP1572962. JD390222 - Sequence 371246 from Patent EP1572962. JD197817 - Sequence 178841 from Patent EP1572962. JD412809 - Sequence 393833 from Patent EP1572962. JD512784 - Sequence 493808 from Patent EP1572962. JD075308 - Sequence 56332 from Patent EP1572962. JD380918 - Sequence 361942 from Patent EP1572962. JD134403 - Sequence 115427 from Patent EP1572962. JD417572 - Sequence 398596 from Patent EP1572962. JD144547 - Sequence 125571 from Patent EP1572962. JD089449 - Sequence 70473 from Patent EP1572962. JD274656 - Sequence 255680 from Patent EP1572962. JD473549 - Sequence 454573 from Patent EP1572962. JD447244 - Sequence 428268 from Patent EP1572962. JD447243 - Sequence 428267 from Patent EP1572962. JD233976 - Sequence 215000 from Patent EP1572962. JD233975 - Sequence 214999 from Patent EP1572962. JD444416 - Sequence 425440 from Patent EP1572962. BC012864 - Homo sapiens adrenomedullin 2, mRNA (cDNA clone IMAGE:3882589), partial cds. JD503996 - Sequence 485020 from Patent EP1572962. JD314951 - Sequence 295975 from Patent EP1572962. JD237085 - Sequence 218109 from Patent EP1572962. JD310217 - Sequence 291241 from Patent EP1572962. JD447060 - Sequence 428084 from Patent EP1572962. JD369555 - Sequence 350579 from Patent EP1572962. JD333103 - Sequence 314127 from Patent EP1572962. JD355630 - Sequence 336654 from Patent EP1572962. JD542090 - Sequence 523114 from Patent EP1572962. JD211041 - Sequence 192065 from Patent EP1572962. JD462076 - Sequence 443100 from Patent EP1572962. JD140858 - Sequence 121882 from Patent EP1572962. JD101412 - Sequence 82436 from Patent EP1572962. JD150613 - Sequence 131637 from Patent EP1572962. JD132909 - Sequence 113933 from Patent EP1572962. JD231584 - Sequence 212608 from Patent EP1572962. JD109653 - Sequence 90677 from Patent EP1572962. JD162353 - Sequence 143377 from Patent EP1572962. JD079224 - Sequence 60248 from Patent EP1572962. JD487155 - Sequence 468179 from Patent EP1572962. JD276184 - Sequence 257208 from Patent EP1572962. JD144120 - Sequence 125144 from Patent EP1572962. JD139344 - Sequence 120368 from Patent EP1572962. JD358052 - Sequence 339076 from Patent EP1572962. JD399689 - Sequence 380713 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q7Z4H4 (Reactome details) participates in the following event(s): R-HSA-420214 The adrenomedullin receptor can bind adrenomedullin and intermedin R-HSA-744886 The Ligand:GPCR:Gs complex dissociates R-HSA-744887 Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs R-HSA-379044 Liganded Gs-activating GPCR acts as a GEF for Gs R-HSA-419812 Calcitonin-like ligand receptors R-HSA-418555 G alpha (s) signalling events R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: ADM2_HUMAN, AM2, ENST00000395737.1, NM_001253845, Q3LFQ0, Q7Z4H4, uc011ary.1, uc011ary.2, uc011ary.3, uc011ary.4 UCSC ID: ENST00000395737.2 RefSeq Accession: NM_001253845.2 Protein: Q7Z4H4 (aka ADM2_HUMAN) CCDS: CCDS33682.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips