Human Gene ADORA2A (ENST00000337539.12) from GENCODE V50

Description: adenosine A2a receptor, transcript variant 4 (from RefSeq NM_001278499.2)
Gencode Transcript: ENST00000337539.12
Gencode Gene: ENSG00000128271.24
Transcript (Including UTRs)
Position: hg38 chr22:24,427,599-24,442,357 Size: 14,759 Total Exon Count: 3 Strand: +
Coding Region
Position: hg38 chr22:24,433,405-24,441,489 Size: 8,085 Coding Exon Count: 2

Page Index	Sequence and Links	Primers	MalaCards	CTD	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways	Other Names
Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:24,427,599-24,442,357)			mRNA (may differ from genome)		Protein (412 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Lynx	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ADORA2A Diseases sorted by gene-association score: acute encephalopathy with biphasic seizures and late reduced diffusion* (25), normal pressure hydrocephalus (7), panic disorder (6), conduct disorder (5), parkinson disease, late-onset (5), basal ganglia disease (5), huntington disease (3), schizophrenia (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002110 Caffeine C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine C098657 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine C081320 8-(3-chlorostyryl)caffeine D000241 Adenosine C097270 ZM 241385 C506291 2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine C524699 5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one D000661 Amphetamine D001564 Benzo(a)pyrene more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.84 RPKM in Liver Total median expression: 9.24 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-218.40	422	-0.518	Picture	PostScript	Text
3' UTR	-346.10	868	-0.399	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD
Protein Sequence	Protein Sequence
Alignment	Alignment

Descriptions from all associated GenBank mRNAs


	AB209022 - Homo sapiens mRNA for KIAA0376 protein variant protein. X68486 - H.sapiens mRNA for A2a adenosine receptor. EU036694 - Homo sapiens adenosine A2A receptor variant 8 mRNA, 5' UTR and partial cds, alternatively spliced. AK123058 - Homo sapiens cDNA FLJ41063 fis, clone THYMU2013950, highly similar to ADENOSINE A2A RECEPTOR. EU036693 - Homo sapiens adenosine A2A receptor variant 7 mRNA, 5' UTR and partial cds, alternatively spliced. AK301420 - Homo sapiens cDNA FLJ61179 complete cds, highly similar to Adenosine A2a receptor. BC013780 - Homo sapiens adenosine A2a receptor, mRNA (cDNA clone MGC:21342 IMAGE:4385637), complete cds. EU036691 - Homo sapiens adenosine A2A receptor variant 5 mRNA, 5' UTR and partial cds, alternatively spliced. EU036692 - Homo sapiens adenosine A2A receptor variant 6 mRNA, 5' UTR and partial cds, alternatively spliced. AK289871 - Homo sapiens cDNA FLJ78315 complete cds, highly similar to Homo sapiens adenosine A2a receptor (ADORA2A), mRNA. AK312946 - Homo sapiens cDNA, FLJ93400, Homo sapiens adenosine A2a receptor (ADORA2A), mRNA. EU036689 - Homo sapiens adenosine A2A receptor variant 3 mRNA, 5' UTR and partial cds, alternatively spliced. EU036690 - Homo sapiens adenosine A2A receptor variant 4 mRNA, 5' UTR and partial cds, alternatively spliced. EU036687 - Homo sapiens adenosine A2A receptor variant 1 mRNA, 5' UTR and partial cds, alternatively spliced. EU036688 - Homo sapiens adenosine A2A receptor variant 2 mRNA, 5' UTR and partial cds, alternatively spliced. S46950 - adenosine A2 receptor [human, hippocampal, mRNA, 2572 nt]. JD453609 - Sequence 434633 from Patent EP1572962. M97370 - Human adenosine receptor (A2) gene, complete cds. JD279765 - Sequence 260789 from Patent EP1572962. CR456367 - Homo sapiens ADORA2A full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.ADORA2A.V2). JD425698 - Sequence 406722 from Patent EP1572962. JD070938 - Sequence 51962 from Patent EP1572962. JD195009 - Sequence 176033 from Patent EP1572962. AB464450 - Synthetic construct DNA, clone: pF1KB8998, Homo sapiens ADORA2A gene for adenosine A2a receptor, without stop codon, in Flexi system. CU013222 - Homo sapiens ADORA2A, mRNA (cDNA clone IMAGE:100000002), complete cds, without stop codon, in Gateway system. CU012934 - Homo sapiens ADORA2A, mRNA (cDNA clone IMAGE:100000098), complete cds, with stop codon, in Gateway system. CU680678 - Synthetic construct Homo sapiens gateway clone IMAGE:100019279 5' read ADORA2A mRNA. KJ896388 - Synthetic construct Homo sapiens clone ccsbBroadEn_05782 ADORA2A gene, encodes complete protein. KJ534761 - Homo sapiens clone ADORA2A_iso-A_adult-A01 adenosine A2a receptor isoform A (ADORA2A) mRNA, partial cds, alternatively spliced. BT006999 - Homo sapiens adenosine A2a receptor mRNA, complete cds. AY136747 - Homo sapiens adenosine receptor A2a (ADORA2A) mRNA, complete cds. JD388522 - Sequence 369546 from Patent EP1572962. JD247225 - Sequence 228249 from Patent EP1572962. JD440623 - Sequence 421647 from Patent EP1572962. JD045370 - Sequence 26394 from Patent EP1572962. JD215892 - Sequence 196916 from Patent EP1572962. JD540503 - Sequence 521527 from Patent EP1572962. JD540504 - Sequence 521528 from Patent EP1572962. JD165618 - Sequence 146642 from Patent EP1572962. JD156034 - Sequence 137058 from Patent EP1572962. JD547920 - Sequence 528944 from Patent EP1572962. JD073135 - Sequence 54159 from Patent EP1572962. JD159499 - Sequence 140523 from Patent EP1572962. JD070608 - Sequence 51632 from Patent EP1572962. JD255072 - Sequence 236096 from Patent EP1572962. JD071643 - Sequence 52667 from Patent EP1572962. JD465577 - Sequence 446601 from Patent EP1572962. JD375264 - Sequence 356288 from Patent EP1572962. JD160692 - Sequence 141716 from Patent EP1572962. JD317740 - Sequence 298764 from Patent EP1572962. JD172551 - Sequence 153575 from Patent EP1572962. JD310941 - Sequence 291965 from Patent EP1572962. JD206626 - Sequence 187650 from Patent EP1572962. JD384539 - Sequence 365563 from Patent EP1572962. JD374005 - Sequence 355029 from Patent EP1572962. JD275187 - Sequence 256211 from Patent EP1572962.

Biochemical and Signaling Pathways


	KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04020 - Calcium signaling pathway hsa04080 - Neuroactive ligand-receptor interaction hsa04270 - Vascular smooth muscle contraction

Other Names for This Gene


	Alternate Gene Symbols: ADORA2A , ENST00000337539.1, ENST00000337539.10, ENST00000337539.11, ENST00000337539.2, ENST00000337539.3, ENST00000337539.4, ENST00000337539.5, ENST00000337539.6, ENST00000337539.7, ENST00000337539.8, ENST00000337539.9, NM_001278499, uc002zzy.1, uc002zzy.2, uc002zzy.3, uc002zzy.4, uc002zzy.5, uc002zzy.6, uc002zzy.7, X5DNB4, X5DNB4_HUMAN UCSC ID: ENST00000337539.12 RefSeq Accession: NM_000675.6 CCDS: CCDS13826.1

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips