Human Gene ADORA2A (ENST00000611543.4) Description and Page Index
  Description: Homo sapiens adenosine A2a receptor (ADORA2A), transcript variant 5, mRNA. (from RefSeq NM_001278500)
RefSeq Summary (NM_001278500): This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013].
Gencode Transcript: ENST00000611543.4
Gencode Gene: ENSG00000128271.22
Transcript (Including UTRs)
   Position: hg38 chr22:24,423,597-24,442,356 Size: 18,760 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chr22:24,433,405-24,441,489 Size: 8,085 Coding Exon Count: 2 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr22:24,423,597-24,442,356)mRNA (may differ from genome)Protein (412 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: ADORA2A
Diseases sorted by gene-association score: acute encephalopathy with biphasic seizures and late reduced diffusion* (25), normal pressure hydrocephalus (7), panic disorder (6), conduct disorder (5), parkinson disease, late-onset (5), basal ganglia disease (5), huntington disease (3), schizophrenia (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D002110 Caffeine
  • C061282 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
  • C098657 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine
  • C081320 8-(3-chlorostyryl)caffeine
  • D000241 Adenosine
  • C097270 ZM 241385
  • C506291 2-n-butyl-9-methyl-8-(1,2,3)triazol-2-yl-9H-purin-6-ylamine
  • C524699 5-(5-amino-3-(4-fluorophenyl)pyrazin-2-yl)-1-isopropylprydine-2(1H)-one
  • D000661 Amphetamine
  • D001564 Benzo(a)pyrene
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.84 RPKM in Liver
Total median expression: 9.24 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -155.20306-0.507 Picture PostScript Text
3' UTR -346.00867-0.399 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AB209022 - Homo sapiens mRNA for KIAA0376 protein variant protein.
X68486 - H.sapiens mRNA for A2a adenosine receptor.
EU036694 - Homo sapiens adenosine A2A receptor variant 8 mRNA, 5' UTR and partial cds, alternatively spliced.
AK123058 - Homo sapiens cDNA FLJ41063 fis, clone THYMU2013950, highly similar to ADENOSINE A2A RECEPTOR.
EU036693 - Homo sapiens adenosine A2A receptor variant 7 mRNA, 5' UTR and partial cds, alternatively spliced.
AK301420 - Homo sapiens cDNA FLJ61179 complete cds, highly similar to Adenosine A2a receptor.
BC013780 - Homo sapiens adenosine A2a receptor, mRNA (cDNA clone MGC:21342 IMAGE:4385637), complete cds.
EU036691 - Homo sapiens adenosine A2A receptor variant 5 mRNA, 5' UTR and partial cds, alternatively spliced.
EU036692 - Homo sapiens adenosine A2A receptor variant 6 mRNA, 5' UTR and partial cds, alternatively spliced.
AK289871 - Homo sapiens cDNA FLJ78315 complete cds, highly similar to Homo sapiens adenosine A2a receptor (ADORA2A), mRNA.
AK312946 - Homo sapiens cDNA, FLJ93400, Homo sapiens adenosine A2a receptor (ADORA2A), mRNA.
EU036689 - Homo sapiens adenosine A2A receptor variant 3 mRNA, 5' UTR and partial cds, alternatively spliced.
EU036690 - Homo sapiens adenosine A2A receptor variant 4 mRNA, 5' UTR and partial cds, alternatively spliced.
EU036687 - Homo sapiens adenosine A2A receptor variant 1 mRNA, 5' UTR and partial cds, alternatively spliced.
EU036688 - Homo sapiens adenosine A2A receptor variant 2 mRNA, 5' UTR and partial cds, alternatively spliced.
S46950 - adenosine A2 receptor [human, hippocampal, mRNA, 2572 nt].
JD453609 - Sequence 434633 from Patent EP1572962.
M97370 - Human adenosine receptor (A2) gene, complete cds.
JD279765 - Sequence 260789 from Patent EP1572962.
CR456367 - Homo sapiens ADORA2A full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.ADORA2A.V2).
JD425698 - Sequence 406722 from Patent EP1572962.
JD070938 - Sequence 51962 from Patent EP1572962.
JD195009 - Sequence 176033 from Patent EP1572962.
AB464450 - Synthetic construct DNA, clone: pF1KB8998, Homo sapiens ADORA2A gene for adenosine A2a receptor, without stop codon, in Flexi system.
CU013222 - Homo sapiens ADORA2A, mRNA (cDNA clone IMAGE:100000002), complete cds, without stop codon, in Gateway system.
CU012934 - Homo sapiens ADORA2A, mRNA (cDNA clone IMAGE:100000098), complete cds, with stop codon, in Gateway system.
CU680678 - Synthetic construct Homo sapiens gateway clone IMAGE:100019279 5' read ADORA2A mRNA.
KJ896388 - Synthetic construct Homo sapiens clone ccsbBroadEn_05782 ADORA2A gene, encodes complete protein.
KJ534761 - Homo sapiens clone ADORA2A_iso-A_adult-A01 adenosine A2a receptor isoform A (ADORA2A) mRNA, partial cds, alternatively spliced.
BT006999 - Homo sapiens adenosine A2a receptor mRNA, complete cds.
AY136747 - Homo sapiens adenosine receptor A2a (ADORA2A) mRNA, complete cds.
JD388522 - Sequence 369546 from Patent EP1572962.
JD247225 - Sequence 228249 from Patent EP1572962.
JD440623 - Sequence 421647 from Patent EP1572962.
JD045370 - Sequence 26394 from Patent EP1572962.
JD215892 - Sequence 196916 from Patent EP1572962.
JD540503 - Sequence 521527 from Patent EP1572962.
JD540504 - Sequence 521528 from Patent EP1572962.
JD165618 - Sequence 146642 from Patent EP1572962.
JD156034 - Sequence 137058 from Patent EP1572962.
JD547920 - Sequence 528944 from Patent EP1572962.
JD073135 - Sequence 54159 from Patent EP1572962.
JD159499 - Sequence 140523 from Patent EP1572962.
JD070608 - Sequence 51632 from Patent EP1572962.
JD255072 - Sequence 236096 from Patent EP1572962.
JD071643 - Sequence 52667 from Patent EP1572962.
JD465577 - Sequence 446601 from Patent EP1572962.
JD375264 - Sequence 356288 from Patent EP1572962.
JD160692 - Sequence 141716 from Patent EP1572962.
JD317740 - Sequence 298764 from Patent EP1572962.
JD172551 - Sequence 153575 from Patent EP1572962.
JD310941 - Sequence 291965 from Patent EP1572962.
JD206626 - Sequence 187650 from Patent EP1572962.
JD384539 - Sequence 365563 from Patent EP1572962.
JD374005 - Sequence 355029 from Patent EP1572962.
JD275187 - Sequence 256211 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04020 - Calcium signaling pathway
hsa04080 - Neuroactive ligand-receptor interaction
hsa04270 - Vascular smooth muscle contraction

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001278500, uc032qjm.1, uc032qjm.2, X5DNB4
UCSC ID: uc032qjm.2
RefSeq Accession: NM_001278500
CCDS: CCDS13826.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.