Human Gene ADPGK (ENST00000456471.3) from GENCODE V50

Description: ADP dependent glucokinase, transcript variant 4 (from RefSeq NM_001365225.1)
Gencode Transcript: ENST00000456471.3
Gencode Gene: ENSG00000159322.20
Transcript (Including UTRs)
Position: hg38 chr15:72,751,294-72,783,758 Size: 32,465 Total Exon Count: 7 Strand: -
Coding Region
Position: hg38 chr15:72,752,341-72,783,691 Size: 31,351 Coding Exon Count: 7

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Methods

Data last updated at UCSC: 2026-07-12 09:30:09

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:72,751,294-72,783,758)			mRNA (may differ from genome)		Protein (497 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	Gencode	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ADPGK_HUMAN DESCRIPTION: RecName: Full=ADP-dependent glucokinase; Short=ADP-GK; Short=ADPGK; EC=2.7.1.147; AltName: Full=RbBP-35; Flags: Precursor; FUNCTION: Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity). CATALYTIC ACTIVITY: ADP + D-glucose = AMP + D-glucose 6-phosphate. COFACTOR: Binds 1 magnesium ion per subunit (By similarity). PATHWAY: Carbohydrate degradation; glycolysis. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Secreted (Potential). SIMILARITY: Belongs to the ADP-dependent glucokinase family. SIMILARITY: Contains 1 ADPK (ADP-dependent kinase) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ADPGK Diseases sorted by gene-association score: monogenic diabetes (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C547126 AZM551248 D000082 Acetaminophen D016604 Aflatoxin B1 D004997 Ethinyl Estradiol D012999 Soman D013629 Tamoxifen D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid more ... click here to view the complete list

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 43.89 RPKM in Spleen Total median expression: 749.54 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-28.70	67	-0.428	Picture	PostScript	Text
3' UTR	-281.00	1047	-0.268	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007666 - ADP_PFK/GK

Pfam Domains:
PF04587 - ADP-specific Phosphofructokinase/Glucokinase conserved region

ModBase Predicted Comparative 3D Structure on Q9BRR6


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
MGI	RGD	Ensembl
Protein Sequence	Protein Sequence	Protein Sequence
Alignment	Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0043843 ADP-specific glucokinase activity GO:0046872 metal ion binding Biological Process: GO:0005975 carbohydrate metabolic process GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0016310 phosphorylation GO:0061621 canonical glycolysis Cellular Component: GO:0005576 extracellular region GO:0005783 endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AF204270 - Homo sapiens RbBP-35 mRNA, complete cds. AL136873 - Homo sapiens mRNA; cDNA DKFZp434B195 (from clone DKFZp434B195). BC044589 - Homo sapiens ADP-dependent glucokinase, mRNA (cDNA clone IMAGE:5269974). AK057651 - Homo sapiens cDNA FLJ33089 fis, clone TRACH2000497, weakly similar to Transacylases. AK075560 - Homo sapiens cDNA PSEC0260 fis, clone NT2RP3004059. AK055526 - Homo sapiens cDNA FLJ30964 fis, clone HEART2000035, weakly similar to Transacylases. AK095995 - Homo sapiens cDNA FLJ38676 fis, clone IMR322000383. AL832254 - Homo sapiens mRNA; cDNA DKFZp667C1917 (from clone DKFZp667C1917). AK293282 - Homo sapiens cDNA FLJ55953 complete cds, highly similar to ADP-dependent glucokinase (EC 2.7.1.147). JD130693 - Sequence 111717 from Patent EP1572962. JD565496 - Sequence 546520 from Patent EP1572962. JD536274 - Sequence 517298 from Patent EP1572962. JD288636 - Sequence 269660 from Patent EP1572962. JD154414 - Sequence 135438 from Patent EP1572962. JD380069 - Sequence 361093 from Patent EP1572962. AK294391 - Homo sapiens cDNA FLJ56905 complete cds, highly similar to ADP-dependent glucokinase (EC 2.7.1.147). JD512953 - Sequence 493977 from Patent EP1572962. JD234573 - Sequence 215597 from Patent EP1572962. JD084753 - Sequence 65777 from Patent EP1572962. JD510168 - Sequence 491192 from Patent EP1572962. CR533447 - Homo sapiens full open reading frame cDNA clone RZPDo834H1116D for gene DKFZP434B195, hypothetical protein DKFZp434B195; complete cds, incl. stopcodon. JD060980 - Sequence 42004 from Patent EP1572962. JD037526 - Sequence 18550 from Patent EP1572962. BC006112 - Homo sapiens ADP-dependent glucokinase, mRNA (cDNA clone MGC:12975 IMAGE:3347312), complete cds. KJ903342 - Synthetic construct Homo sapiens clone ccsbBroadEn_12736 ADPGK gene, encodes complete protein. KJ905562 - Synthetic construct Homo sapiens clone ccsbBroadEn_15178 ADPGK gene, encodes complete protein. EU831454 - Synthetic construct Homo sapiens clone HAIB:100066483; DKFZo008E0617 ADP-dependent glucokinase protein (ADPGK) gene, encodes complete protein. EU831541 - Synthetic construct Homo sapiens clone HAIB:100066570; DKFZo004E0618 ADP-dependent glucokinase protein (ADPGK) gene, encodes complete protein. CU675251 - Synthetic construct Homo sapiens gateway clone IMAGE:100019680 5' read ADPGK mRNA. BC018074 - Homo sapiens ADP-dependent glucokinase, mRNA (cDNA clone IMAGE:4791959), complete cds. JD406653 - Sequence 387677 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9BRR6 (Reactome details) participates in the following event(s): R-HSA-5696021 ADPGK:Mg2+ phosphorylates Glc to G6P R-HSA-70171 Glycolysis R-HSA-70326 Glucose metabolism R-HSA-71387 Metabolism of carbohydrates R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: ADPGK_HUMAN, ENST00000456471.1, ENST00000456471.2, NM_001365225, PSEC0260, Q49AU7, Q8NBI1, Q8WZ90, Q96NF8, Q9BRR6, Q9H0A7, uc059ldf.1, uc059ldf.2 UCSC ID: ENST00000456471.3 RefSeq Accession: NM_001365225.1 Protein: Q9BRR6 (aka ADPGK_HUMAN)

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

GNF Expression Atlas 2 Data from U133A and GNF1H Chips