Human Gene GRK3 (ENST00000324198.11) Description and Page Index
Description: Homo sapiens G protein-coupled receptor kinase 3 (GRK3), mRNA. (from RefSeq NM_005160) RefSeq Summary (NM_005160): The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and ESTs. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.49367.1, SRR5189667.339304.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324198.11/ ENSP00000317578.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000324198.11 Gencode Gene: ENSG00000100077.15 Transcript (Including UTRs) Position: hg38 chr22:25,564,675-25,729,294 Size: 164,620 Total Exon Count: 21 Strand: + Coding Region Position: hg38 chr22:25,565,041-25,722,450 Size: 157,410 Coding Exon Count: 21
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00169 - PH domain PF00069 - Protein kinase domain PF00615 - Regulator of G protein signaling domain
ModBase Predicted Comparative 3D Structure on P35626
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.