Human Gene AGR2 (ENST00000419304.7) from GENCODE V44
Description: Homo sapiens anterior gradient 2, protein disulphide isomerase family member (AGR2), mRNA. (from RefSeq NM_006408) RefSeq Summary (NM_006408): This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]. Gencode Transcript: ENST00000419304.7 Gencode Gene: ENSG00000106541.12 Transcript (Including UTRs) Position: hg38 chr7:16,791,811-16,804,999 Size: 13,189 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr7:16,792,908-16,801,796 Size: 8,889 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q4JM46
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
