Human Gene AKT3 (ENST00000673466.1) Description and Page Index
  Description: Homo sapiens AKT serine/threonine kinase 3 (AKT3), transcript variant 1, mRNA. (from RefSeq NM_005465)
RefSeq Summary (NM_005465): The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000673466.1
Gencode Gene: ENSG00000117020.18
Transcript (Including UTRs)
   Position: hg38 chr1:243,499,724-243,850,243 Size: 350,520 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr1:243,505,249-243,843,170 Size: 337,922 Coding Exon Count: 13 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesGeneReviews
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:243,499,724-243,850,243)mRNA (may differ from genome)Protein (479 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  MalaCards Disease Associations
  MalaCards Gene Search: AKT3
Diseases sorted by gene-association score: megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2* (1331), hemimegalencephaly* (367), megalencephaly-capillary malformation-polymicrogyria syndrome, somatic* (283), mpph syndrome* (202), thymoma (25), megalencephaly (22), glioma (20), glioblastoma (19), glioblastoma multiforme (16), hydrocephalus (10), hypomelanosis of ito (9), corneal fleck dystrophy (8), proteus syndrome, somatic (8), melanoma (7), corpus callosum agenesis (5), hypoparathyroidism-deafness-renal disease syndrome (5), epileptic encephalopathy, early infantile, 15 (4), heterotopia, periventricular (4), muenke syndrome (4), lennox-gastaut syndrome (3), prostate cancer (1), congenital nervous system abnormality (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.63 RPKM in Artery - Tibial
Total median expression: 427.17 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -159.50316-0.505 Picture PostScript Text
3' UTR -1491.205525-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  LF383661 - JP 2014500723-A/191164: Polycomb-Associated Non-Coding RNAs.
MA619238 - JP 2018138019-A/191164: Polycomb-Associated Non-Coding RNAs.
AY005799 - Homo sapiens protein kinase B gamma 1 (AKT3) mRNA, complete cds, alternatively spliced.
LF385478 - JP 2014500723-A/192981: Polycomb-Associated Non-Coding RNAs.
MA621055 - JP 2018138019-A/192981: Polycomb-Associated Non-Coding RNAs.
BC121154 - Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone MGC:150492 IMAGE:40121374), complete cds.
AL117525 - Homo sapiens mRNA; cDNA DKFZp434N0250 (from clone DKFZp434N0250).
LF205481 - JP 2014500723-A/12984: Polycomb-Associated Non-Coding RNAs.
MA441058 - JP 2018138019-A/12984: Polycomb-Associated Non-Coding RNAs.
KJ898135 - Synthetic construct Homo sapiens clone ccsbBroadEn_07529 AKT3 gene, encodes complete protein.
AB463341 - Synthetic construct DNA, clone: pF1KB8397, Homo sapiens AKT3 gene for v-akt murine thymoma viral oncogene homolog 3, without stop codon, in Flexi system.
AM392791 - Synthetic construct Homo sapiens clone IMAGE:100002102 for hypothetical protein (AKT3 gene).
AM392849 - Synthetic construct Homo sapiens clone IMAGE:100001651 for hypothetical protein (AKT3 gene).
AF135794 - Homo sapiens AKT3 protein kinase mRNA, complete cds.
AF124141 - Homo sapiens protein kinase B gamma mRNA, complete cds.
AF085234 - Homo sapiens STK-2 mRNA, complete cds.
AK308052 - Homo sapiens cDNA, FLJ98000.
AJ245709 - Homo sapiens mRNA for serine/threonine kinase Akt-3 (Akt3 gene).
BC020479 - Homo sapiens v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma), mRNA (cDNA clone IMAGE:3867931), partial cds.
U79271 - Human clones 23920 and 23921 mRNA sequence.
LF320908 - JP 2014500723-A/128411: Polycomb-Associated Non-Coding RNAs.
MA556485 - JP 2018138019-A/128411: Polycomb-Associated Non-Coding RNAs.
LF320909 - JP 2014500723-A/128412: Polycomb-Associated Non-Coding RNAs.
MA556486 - JP 2018138019-A/128412: Polycomb-Associated Non-Coding RNAs.
AL080074 - Homo sapiens mRNA; cDNA DKFZp564B0262 (from clone DKFZp564B0262).
AK055109 - Homo sapiens cDNA FLJ30547 fis, clone BRAWH2001439.
BC019085 - Homo sapiens cDNA clone IMAGE:4870417, partial cds.
LF320910 - JP 2014500723-A/128413: Polycomb-Associated Non-Coding RNAs.
MA556487 - JP 2018138019-A/128413: Polycomb-Associated Non-Coding RNAs.
LF320911 - JP 2014500723-A/128414: Polycomb-Associated Non-Coding RNAs.
MA556488 - JP 2018138019-A/128414: Polycomb-Associated Non-Coding RNAs.
JD357007 - Sequence 338031 from Patent EP1572962.
JD190059 - Sequence 171083 from Patent EP1572962.
JD211684 - Sequence 192708 from Patent EP1572962.
JD377231 - Sequence 358255 from Patent EP1572962.
JD378452 - Sequence 359476 from Patent EP1572962.
JD524983 - Sequence 506007 from Patent EP1572962.
JD378451 - Sequence 359475 from Patent EP1572962.
JD295578 - Sequence 276602 from Patent EP1572962.
JD300746 - Sequence 281770 from Patent EP1572962.
JD110152 - Sequence 91176 from Patent EP1572962.
JD163825 - Sequence 144849 from Patent EP1572962.
JD228886 - Sequence 209910 from Patent EP1572962.
DJ444891 - Combinatorial Methods and Compositions for Treatment of Melanoma.
DJ444896 - Combinatorial Methods and Compositions for Treatment of Melanoma.
DJ444889 - Combinatorial Methods and Compositions for Treatment of Melanoma.
LF320915 - JP 2014500723-A/128418: Polycomb-Associated Non-Coding RNAs.
MA556492 - JP 2018138019-A/128418: Polycomb-Associated Non-Coding RNAs.
LF320918 - JP 2014500723-A/128421: Polycomb-Associated Non-Coding RNAs.
MA556495 - JP 2018138019-A/128421: Polycomb-Associated Non-Coding RNAs.
DJ444887 - Combinatorial Methods and Compositions for Treatment of Melanoma.
LF320919 - JP 2014500723-A/128422: Polycomb-Associated Non-Coding RNAs.
MA556496 - JP 2018138019-A/128422: Polycomb-Associated Non-Coding RNAs.
LF320920 - JP 2014500723-A/128423: Polycomb-Associated Non-Coding RNAs.
MA556497 - JP 2018138019-A/128423: Polycomb-Associated Non-Coding RNAs.
KJ452457 - Homo sapiens PVT1/AKT3 fusion protein isoform 2 mRNA, partial cds.
LF320923 - JP 2014500723-A/128426: Polycomb-Associated Non-Coding RNAs.
MA556500 - JP 2018138019-A/128426: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04012 - ErbB signaling pathway
hsa04062 - Chemokine signaling pathway
hsa04150 - mTOR signaling pathway
hsa04210 - Apoptosis
hsa04370 - VEGF signaling pathway
hsa04510 - Focal adhesion
hsa04530 - Tight junction
hsa04620 - Toll-like receptor signaling pathway
hsa04630 - Jak-STAT signaling pathway
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04664 - Fc epsilon RI signaling pathway
hsa04666 - Fc gamma R-mediated phagocytosis
hsa04722 - Neurotrophin signaling pathway
hsa04910 - Insulin signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa04920 - Adipocytokine signaling pathway
hsa05142 - Chagas disease
hsa05200 - Pathways in cancer
hsa05210 - Colorectal cancer
hsa05211 - Renal cell carcinoma
hsa05212 - Pancreatic cancer
hsa05213 - Endometrial cancer
hsa05214 - Glioma
hsa05215 - Prostate cancer
hsa05218 - Melanoma
hsa05220 - Chronic myeloid leukemia
hsa05221 - Acute myeloid leukemia
hsa05222 - Small cell lung cancer
hsa05223 - Non-small cell lung cancer

-  Other Names for This Gene
  Alternate Gene Symbols: NM_005465, uc288mcn.1
UCSC ID: uc288mcn.1
RefSeq Accession: NM_005465
CCDS: CCDS31077.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene AKT3:
mpph (MPPH Syndrome)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.