Human Gene ALDH16A1 (ENST00000293350.9) from GENCODE V44
Description: Homo sapiens aldehyde dehydrogenase 16 family member A1 (ALDH16A1), transcript variant 1, mRNA. (from RefSeq NM_153329) RefSeq Summary (NM_153329): This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]. Gencode Transcript: ENST00000293350.9 Gencode Gene: ENSG00000161618.10 Transcript (Including UTRs) Position: hg38 chr19:49,453,225-49,471,050 Size: 17,826 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr19:49,453,332-49,470,467 Size: 17,136 Coding Exon Count: 17
ID:A16A1_HUMAN DESCRIPTION: RecName: Full=Aldehyde dehydrogenase family 16 member A1; SUBUNIT: Interacts with SPG21. SIMILARITY: Belongs to the aldehyde dehydrogenase family. CAUTION: The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure. SEQUENCE CAUTION: Sequence=AAH35641.1; Type=Erroneous initiation; Sequence=BAB84962.1; Type=Erroneous translation; Note=Wrong choice of frame;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00171 - Aldehyde dehydrogenase family
ModBase Predicted Comparative 3D Structure on Q8IZ83
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process: GO:0008152 metabolic process GO:0055114 oxidation-reduction process
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