ID:AL3B1_HUMAN DESCRIPTION: RecName: Full=Aldehyde dehydrogenase family 3 member B1; EC=1.2.1.5; AltName: Full=Aldehyde dehydrogenase 7; FUNCTION: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H. PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. TISSUE SPECIFICITY: Highest expression in kidney and lung. SIMILARITY: Belongs to the aldehyde dehydrogenase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00171 - Aldehyde dehydrogenase family
ModBase Predicted Comparative 3D Structure on P43353
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004028 3-chloroallyl aldehyde dehydrogenase activity GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process: GO:0006066 alcohol metabolic process GO:0006068 ethanol catabolic process GO:0006081 cellular aldehyde metabolic process GO:0006629 lipid metabolic process GO:0008152 metabolic process GO:0030148 sphingolipid biosynthetic process GO:0034599 cellular response to oxidative stress GO:0043312 neutrophil degranulation GO:0046185 aldehyde catabolic process GO:0055114 oxidation-reduction process
Sequence and Links to Tools and Databases 
Microarray Expression Data 
