ID:ANO1_HUMAN DESCRIPTION: RecName: Full=Anoctamin-1; AltName: Full=Discovered on gastrointestinal stromal tumors protein 1; AltName: Full=Oral cancer overexpressed protein 2; AltName: Full=Transmembrane protein 16A; AltName: Full=Tumor-amplified and overexpressed sequence 2; FUNCTION: Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. TISSUE SPECIFICITY: Broadly expressed with higher levels in liver and skeletal muscle. DOMAIN: The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region (By similarity). SIMILARITY: Belongs to the anoctamin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5XXA6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006812 cation transport GO:0006821 chloride transport GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007275 multicellular organism development GO:0015705 iodide transport GO:0034220 ion transmembrane transport GO:0034605 cellular response to heat GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:1902476 chloride transmembrane transport