Human Gene APMAP (ENST00000217456.3) from GENCODE V44
  Description: Homo sapiens adipocyte plasma membrane associated protein (APMAP), mRNA. (from RefSeq NM_020531)
Gencode Transcript: ENST00000217456.3
Gencode Gene: ENSG00000101474.12
Transcript (Including UTRs)
   Position: hg38 chr20:24,962,925-24,992,751 Size: 29,827 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr20:24,963,813-24,992,688 Size: 28,876 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:24,962,925-24,992,751)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: APMAP_HUMAN
DESCRIPTION: RecName: Full=Adipocyte plasma membrane-associated protein; AltName: Full=Protein BSCv;
FUNCTION: Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Liver, glomerular and tubular structures of the kidney, endothelial cells, arterial wall and pancreatic islets of Langerhans (at protein level). Found ubiquitously in adult as well as in embryonic tissues. In adult tissue, the highest expression is found in the liver, placenta and heart. Found on the cell surface of monocytes. In embryonic tissue, the highest expression levels is found in the liver and the kidney.
SIMILARITY: Belongs to the strictosidine synthase family.
SEQUENCE CAUTION: Sequence=AAQ89435.1; Type=Erroneous initiation; Sequence=BAB11885.1; Type=Erroneous initiation; Sequence=BAB15253.1; Type=Erroneous initiation; Sequence=BAB15578.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 125.96 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 2200.02 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.6063-0.343 Picture PostScript Text
3' UTR -295.90888-0.333 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011042 - 6-blade_b-propeller_TolB-like
IPR018119 - Strictosidine_synth_cons-reg

Pfam Domains:
PF03088 - Strictosidine synthase

ModBase Predicted Comparative 3D Structure on Q9HDC9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsemblWormBase 
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004064 arylesterase activity
GO:0016844 strictosidine synthase activity

Biological Process:
GO:0008150 biological_process
GO:0009058 biosynthetic process

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK025834 - Homo sapiens cDNA: FLJ22181 fis, clone HRC00945.
AK026866 - Homo sapiens cDNA: FLJ23213 fis, clone ADSU01581.
BC003501 - Homo sapiens chromosome 20 open reading frame 3, mRNA (cDNA clone MGC:10335 IMAGE:3530962), complete cds.
AB033767 - Homo sapiens BSCv mRNA, partial cds.
AY359076 - Homo sapiens clone DNA84141 C20orf3 (UNQ1869) mRNA, complete cds.
JD087284 - Sequence 68308 from Patent EP1572962.
JD172950 - Sequence 153974 from Patent EP1572962.
JD558003 - Sequence 539027 from Patent EP1572962.
JD439312 - Sequence 420336 from Patent EP1572962.
JD355549 - Sequence 336573 from Patent EP1572962.
JD457637 - Sequence 438661 from Patent EP1572962.
JD043630 - Sequence 24654 from Patent EP1572962.
JD368940 - Sequence 349964 from Patent EP1572962.
JD176939 - Sequence 157963 from Patent EP1572962.
JD403042 - Sequence 384066 from Patent EP1572962.
AK291129 - Homo sapiens cDNA FLJ76183 complete cds.
AK301959 - Homo sapiens cDNA FLJ58338 complete cds, highly similar to Adipocyte plasma membrane-associated protein.
JD494696 - Sequence 475720 from Patent EP1572962.
JD276882 - Sequence 257906 from Patent EP1572962.
JD276881 - Sequence 257905 from Patent EP1572962.
JD279122 - Sequence 260146 from Patent EP1572962.
JD057051 - Sequence 38075 from Patent EP1572962.
DQ584281 - Homo sapiens piRNA piR-51393, complete sequence.
HQ447266 - Synthetic construct Homo sapiens clone IMAGE:100070576; CCSB004216_02 chromosome 20 open reading frame 3 (C20orf3) gene, encodes complete protein.
CU678464 - Synthetic construct Homo sapiens gateway clone IMAGE:100019297 5' read C20orf3 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K514, APMAP_HUMAN, B4DXG1, C20orf3, ENST00000217456.1, ENST00000217456.2, NM_020531, Q6UVZ8, Q9GZS8, Q9HDC9, Q9NUB2, uc002wty.1, uc002wty.2, uc002wty.3, uc002wty.4, uc002wty.5, UNQ1869/PRO4305
UCSC ID: ENST00000217456.3
RefSeq Accession: NM_020531
Protein: Q9HDC9 (aka APMAP_HUMAN or APMA_HUMAN)
CCDS: CCDS13166.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.