Human Gene ARF4 (ENST00000303436.11) from GENCODE V44
Description: Homo sapiens ADP ribosylation factor 4 (ARF4), mRNA. (from RefSeq NM_001660) RefSeq Summary (NM_001660): This gene is a member of the human ARF gene family whose members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute one family of the RAS superfamily. The ARF proteins are categorized as class I, class II and class III; this gene is a class II member. The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. This gene is the most divergent member of the human ARFs. Conflicting map positions at 3p14 or 3p21 have been reported for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000303436.11 Gencode Gene: ENSG00000168374.11 Transcript (Including UTRs) Position: hg38 chr3:57,571,363-57,597,344 Size: 25,982 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr3:57,572,212-57,597,140 Size: 24,929 Coding Exon Count: 6
ID:ARF4_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor 4; FUNCTION: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. INTERACTION: Q96PM5:RCHY1; NbExp=3; IntAct=EBI-1237085, EBI-947779; SUBCELLULAR LOCATION: Golgi apparatus. SIMILARITY: Belongs to the small GTPase superfamily. Arf family. CAUTION: Was originally thought to be ARF2.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P18085
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006471 protein ADP-ribosylation GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007173 epidermal growth factor receptor signaling pathway GO:0007420 brain development GO:0007612 learning GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0016477 cell migration GO:0031584 activation of phospholipase D activity GO:0043066 negative regulation of apoptotic process GO:0045176 apical protein localization GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048678 response to axon injury GO:0060996 dendritic spine development GO:0061512 protein localization to cilium GO:2000377 regulation of reactive oxygen species metabolic process
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