ID:ARHGC_HUMAN DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 12; AltName: Full=Leukemia-associated RhoGEF; FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. SUBUNIT: Interacts with GNA12 and GNA13, probably through the RGS- like domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts through its PDZ domain with IGF1R beta subunit. Interacts with GCSAM. SUBCELLULAR LOCATION: Cytoplasm (Probable). Membrane (Probable). Note=Translocated to the membrane upon stimulation (Probable). TISSUE SPECIFICITY: Ubiquitously expressed. Isoform 2 is found in jejunum and testis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PDZ (DHR) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 RGSL (RGS-like) domain. SEQUENCE CAUTION: Sequence=AAH63117.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/LARGID243.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZN5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007186 G-protein coupled receptor signaling pathway GO:0007266 Rho protein signal transduction GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0043547 positive regulation of GTPase activity GO:0051056 regulation of small GTPase mediated signal transduction
Sequence and Links to Tools and Databases 
Microarray Expression Data 
