Human Gene ARL11 (ENST00000282026.2) from GENCODE V44
Description: Homo sapiens ADP ribosylation factor like GTPase 11 (ARL11), mRNA. (from RefSeq NM_138450) RefSeq Summary (NM_138450): This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000282026.2 Gencode Gene: ENSG00000152213.4 Transcript (Including UTRs) Position: hg38 chr13:49,628,507-49,633,872 Size: 5,366 Total Exon Count: 2 Strand: + Coding Region Position: hg38 chr13:49,630,448-49,631,038 Size: 591 Coding Exon Count: 1
ID:ARL11_HUMAN DESCRIPTION: RecName: Full=ADP-ribosylation factor-like protein 11; AltName: Full=ADP-ribosylation factor-like tumor suppressor protein 1; FUNCTION: May play a role in apoptosis. May act as a tumor suppressor. INTERACTION: Q15645:TRIP13; NbExp=3; IntAct=EBI-751892, EBI-358993; TISSUE SPECIFICITY: Expressed in lung and leukocytes. DISEASE: Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL) [MIM:151400]. SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family
ModBase Predicted Comparative 3D Structure on Q969Q4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.