Human Gene ARL11 (ENST00000282026.2) from GENCODE V44
  Description: Homo sapiens ADP ribosylation factor like GTPase 11 (ARL11), mRNA. (from RefSeq NM_138450)
RefSeq Summary (NM_138450): This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010].
Gencode Transcript: ENST00000282026.2
Gencode Gene: ENSG00000152213.4
Transcript (Including UTRs)
   Position: hg38 chr13:49,628,507-49,633,872 Size: 5,366 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr13:49,630,448-49,631,038 Size: 591 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr13:49,628,507-49,633,872)mRNA (may differ from genome)Protein (196 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ARL11_HUMAN
DESCRIPTION: RecName: Full=ADP-ribosylation factor-like protein 11; AltName: Full=ADP-ribosylation factor-like tumor suppressor protein 1;
FUNCTION: May play a role in apoptosis. May act as a tumor suppressor.
INTERACTION: Q15645:TRIP13; NbExp=3; IntAct=EBI-751892, EBI-358993;
TISSUE SPECIFICITY: Expressed in lung and leukocytes.
DISEASE: Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL) [MIM:151400].
SIMILARITY: Belongs to the small GTPase superfamily. Arf family.

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ARL11
Diseases sorted by gene-association score: ovarian cystadenocarcinoma (9), chronic lymphocytic leukemia* (7), chronic leukemia (7), dysplastic nevus syndrome (7), ovary adenocarcinoma (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.15 RPKM in Whole Blood
Total median expression: 27.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -36.00127-0.283 Picture PostScript Text
3' UTR -842.302834-0.297 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR024156 - Small_GTPase_ARF
IPR006689 - Small_GTPase_ARF/SAR

Pfam Domains:
PF00025 - ADP-ribosylation factor family

ModBase Predicted Comparative 3D Structure on Q969Q4
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005525 GTP binding

Biological Process:
GO:0002244 hematopoietic progenitor cell differentiation

Cellular Component:
GO:0005622 intracellular


-  Descriptions from all associated GenBank mRNAs
  AF441378 - Homo sapiens ADP-ribosylation factor-like tumor suppressor protein 1 (ARLTS1) mRNA, complete cds.
LF384996 - JP 2014500723-A/192499: Polycomb-Associated Non-Coding RNAs.
MA620573 - JP 2018138019-A/192499: Polycomb-Associated Non-Coding RNAs.
LF214012 - JP 2014500723-A/21515: Polycomb-Associated Non-Coding RNAs.
MA449589 - JP 2018138019-A/21515: Polycomb-Associated Non-Coding RNAs.
AK091249 - Homo sapiens cDNA FLJ33930 fis, clone CTONG2017604, weakly similar to ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3.
AX746876 - Sequence 401 from Patent EP1308459.
BC015866 - Homo sapiens mRNA similar to hypothetical protein FLJ22595 (cDNA clone IMAGE:4697740).
BC013150 - Homo sapiens ADP-ribosylation factor-like 11, mRNA (cDNA clone MGC:17429 IMAGE:4340470), complete cds.
JD334463 - Sequence 315487 from Patent EP1572962.
JD404730 - Sequence 385754 from Patent EP1572962.
JD206952 - Sequence 187976 from Patent EP1572962.
AB464453 - Synthetic construct DNA, clone: pF1KB8753, Homo sapiens ARL11 gene for ADP-ribosylation factor-like 11, without stop codon, in Flexi system.
KJ895291 - Synthetic construct Homo sapiens clone ccsbBroadEn_04685 ARL11 gene, encodes complete protein.
KR709421 - Synthetic construct Homo sapiens clone CCSBHm_00002054 ARL11 (ARL11) mRNA, encodes complete protein.
JD336590 - Sequence 317614 from Patent EP1572962.
JD478554 - Sequence 459578 from Patent EP1572962.
JD463796 - Sequence 444820 from Patent EP1572962.
JD463795 - Sequence 444819 from Patent EP1572962.
JD148284 - Sequence 129308 from Patent EP1572962.
JD148283 - Sequence 129307 from Patent EP1572962.
JD249813 - Sequence 230837 from Patent EP1572962.
JD100947 - Sequence 81971 from Patent EP1572962.
JD058048 - Sequence 39072 from Patent EP1572962.
JD498757 - Sequence 479781 from Patent EP1572962.
JD485287 - Sequence 466311 from Patent EP1572962.
JD520084 - Sequence 501108 from Patent EP1572962.
JD201402 - Sequence 182426 from Patent EP1572962.
JD430887 - Sequence 411911 from Patent EP1572962.
JD430888 - Sequence 411912 from Patent EP1572962.
JD558688 - Sequence 539712 from Patent EP1572962.
JD532183 - Sequence 513207 from Patent EP1572962.
JD442787 - Sequence 423811 from Patent EP1572962.
JD442788 - Sequence 423812 from Patent EP1572962.
JD335087 - Sequence 316111 from Patent EP1572962.
JD335088 - Sequence 316112 from Patent EP1572962.
JD456436 - Sequence 437460 from Patent EP1572962.
JD120883 - Sequence 101907 from Patent EP1572962.
JD120884 - Sequence 101908 from Patent EP1572962.
JD380576 - Sequence 361600 from Patent EP1572962.
JD497849 - Sequence 478873 from Patent EP1572962.
JD452269 - Sequence 433293 from Patent EP1572962.
JD079504 - Sequence 60528 from Patent EP1572962.
JD493666 - Sequence 474690 from Patent EP1572962.
JD351812 - Sequence 332836 from Patent EP1572962.
JD523739 - Sequence 504763 from Patent EP1572962.
JD247769 - Sequence 228793 from Patent EP1572962.
JD430129 - Sequence 411153 from Patent EP1572962.
JD557300 - Sequence 538324 from Patent EP1572962.
JD557299 - Sequence 538323 from Patent EP1572962.
JD529110 - Sequence 510134 from Patent EP1572962.
JD529111 - Sequence 510135 from Patent EP1572962.
JD529109 - Sequence 510133 from Patent EP1572962.
JD169183 - Sequence 150207 from Patent EP1572962.
JD169185 - Sequence 150209 from Patent EP1572962.
JD169186 - Sequence 150210 from Patent EP1572962.
JD169184 - Sequence 150208 from Patent EP1572962.
JD041220 - Sequence 22244 from Patent EP1572962.
JD041219 - Sequence 22243 from Patent EP1572962.
JD320966 - Sequence 301990 from Patent EP1572962.
JD320967 - Sequence 301991 from Patent EP1572962.
JD335283 - Sequence 316307 from Patent EP1572962.
JD387956 - Sequence 368980 from Patent EP1572962.
JD335284 - Sequence 316308 from Patent EP1572962.
JD387957 - Sequence 368981 from Patent EP1572962.
JD387959 - Sequence 368983 from Patent EP1572962.
JD118046 - Sequence 99070 from Patent EP1572962.
JD447143 - Sequence 428167 from Patent EP1572962.
JD138481 - Sequence 119505 from Patent EP1572962.
JD176574 - Sequence 157598 from Patent EP1572962.
JD531884 - Sequence 512908 from Patent EP1572962.
JD176575 - Sequence 157599 from Patent EP1572962.
JD066845 - Sequence 47869 from Patent EP1572962.
JD066846 - Sequence 47870 from Patent EP1572962.
JD184236 - Sequence 165260 from Patent EP1572962.
JD093127 - Sequence 74151 from Patent EP1572962.
JD561549 - Sequence 542573 from Patent EP1572962.
JD282402 - Sequence 263426 from Patent EP1572962.
JD231228 - Sequence 212252 from Patent EP1572962.
JD272639 - Sequence 253663 from Patent EP1572962.
JD391101 - Sequence 372125 from Patent EP1572962.
JD278945 - Sequence 259969 from Patent EP1572962.
JD140344 - Sequence 121368 from Patent EP1572962.
JD531068 - Sequence 512092 from Patent EP1572962.
JD565400 - Sequence 546424 from Patent EP1572962.
JD507709 - Sequence 488733 from Patent EP1572962.
JD400486 - Sequence 381510 from Patent EP1572962.
JD187885 - Sequence 168909 from Patent EP1572962.
JD550862 - Sequence 531886 from Patent EP1572962.
JD040405 - Sequence 21429 from Patent EP1572962.
JD242157 - Sequence 223181 from Patent EP1572962.
JD272476 - Sequence 253500 from Patent EP1572962.
JD342676 - Sequence 323700 from Patent EP1572962.
JD370339 - Sequence 351363 from Patent EP1572962.
JD185027 - Sequence 166051 from Patent EP1572962.
JD065996 - Sequence 47020 from Patent EP1572962.
JD445321 - Sequence 426345 from Patent EP1572962.
JD482089 - Sequence 463113 from Patent EP1572962.
JD302782 - Sequence 283806 from Patent EP1572962.
JD085215 - Sequence 66239 from Patent EP1572962.
JD313007 - Sequence 294031 from Patent EP1572962.
JD342765 - Sequence 323789 from Patent EP1572962.
JD540701 - Sequence 521725 from Patent EP1572962.
JD306641 - Sequence 287665 from Patent EP1572962.
JD110910 - Sequence 91934 from Patent EP1572962.
JD050486 - Sequence 31510 from Patent EP1572962.
JD301684 - Sequence 282708 from Patent EP1572962.
JD060385 - Sequence 41409 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ARL11_HUMAN, ARLTS1, ENST00000282026.1, NM_138450, Q969Q4, uc001vdf.1, uc001vdf.2, uc001vdf.3
UCSC ID: ENST00000282026.2
RefSeq Accession: NM_138450
Protein: Q969Q4 (aka ARL11_HUMAN)
CCDS: CCDS9419.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.