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Human Gene ARMCX3 (ENST00000471229.7) from GENCODE V50
  Description: armadillo repeat containing X-linked 3, transcript variant 2 (from RefSeq NM_177947.3)
Gencode Transcript: ENST00000471229.7
Gencode Gene: ENSG00000102401.22
Transcript (Including UTRs)
   Position: hg38 chrX:101,623,151-101,627,843 Size: 4,693 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chrX:101,624,980-101,626,119 Size: 1,140 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: ARMX3_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing X-linked protein 3; AltName: Full=ARM protein lost in epithelial cancers on chromosome X 3; Short=Protein ALEX3;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Contains 3 ARM repeats.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALEX3Xq22ID479.html";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 34.90 RPKM in Pituitary
Total median expression: 959.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.10484-0.362 Picture PostScript Text
3' UTR -418.501724-0.243 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR006911 - ARM-rpt_dom
IPR016024 - ARM-type_fold
IPR000225 - Armadillo

Pfam Domains:
PF04826 - Armadillo-like

ModBase Predicted Comparative 3D Structure on Q9UH62
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0034613 cellular protein localization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane


-  Descriptions from all associated GenBank mRNAs
  AK291225 - Homo sapiens cDNA FLJ75682 complete cds, highly similar to Homo sapiens armadillo repeat containing, X-linked 3 (ARMCX3), transcript variant 1, mRNA.
JD535037 - Sequence 516061 from Patent EP1572962.
BX647802 - Homo sapiens mRNA; cDNA DKFZp686F0796 (from clone DKFZp686F0796).
JD227387 - Sequence 208411 from Patent EP1572962.
AF208859 - Homo sapiens BM-017 mRNA, complete cds.
AK222655 - Homo sapiens mRNA for ALEX3 protein variant, clone: CBR00185.
AB039669 - Homo sapiens mRNA for ALEX3, complete cds.
BC005194 - Homo sapiens armadillo repeat containing, X-linked 3, mRNA (cDNA clone MGC:12199 IMAGE:3932220), complete cds.
CR933656 - Homo sapiens mRNA; cDNA DKFZp781N1954 (from clone DKFZp781N1954).
JD157522 - Sequence 138546 from Patent EP1572962.
JD062555 - Sequence 43579 from Patent EP1572962.
JD062556 - Sequence 43580 from Patent EP1572962.
JD208114 - Sequence 189138 from Patent EP1572962.
JD530342 - Sequence 511366 from Patent EP1572962.
JD336360 - Sequence 317384 from Patent EP1572962.
JD062740 - Sequence 43764 from Patent EP1572962.
AF211175 - Homo sapiens unknown mRNA.
JD182596 - Sequence 163620 from Patent EP1572962.
AY359079 - Homo sapiens clone DNA98593 ALEX3 (UNQ2517) mRNA, complete cds.
JD292874 - Sequence 273898 from Patent EP1572962.
KJ893941 - Synthetic construct Homo sapiens clone ccsbBroadEn_03335 ARMCX3 gene, encodes complete protein.
AB464461 - Synthetic construct DNA, clone: pF1KB8816, Homo sapiens ARMCX3 gene for armadillo repeat containing, X-linked 3, without stop codon, in Flexi system.
DQ896280 - Synthetic construct Homo sapiens clone IMAGE:100010740; FLH192894.01L; RZPDo839A0768D armadillo repeat containing, X-linked 3 (ARMCX3) gene, encodes complete protein.
DQ893039 - Synthetic construct clone IMAGE:100005669; FLH192898.01X; RZPDo839A0778D armadillo repeat containing, X-linked 3 (ARMCX3) gene, encodes complete protein.
JD313369 - Sequence 294393 from Patent EP1572962.
JD491038 - Sequence 472062 from Patent EP1572962.
DL492248 - Novel nucleic acids.
JD019157 - Sequence 181 from Patent EP1572962.
JD035969 - Sequence 16993 from Patent EP1572962.
JD029138 - Sequence 10162 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ALEX3, ARMX3_HUMAN, BM-017, ENST00000471229.1, ENST00000471229.2, ENST00000471229.3, ENST00000471229.4, ENST00000471229.5, ENST00000471229.6, NM_177947, Q53HC6, Q7LCF5, Q9NPE4, Q9UH62, uc004eia.1, uc004eia.2, uc004eia.3, UNQ2517/PRO6007
UCSC ID: ENST00000471229.7
RefSeq Accession: NM_177947.3
Protein: Q9UH62 (aka ARMX3_HUMAN)
CCDS: CCDS14489.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.