Human Gene ATP5F1B (ENST00000262030.8) from GENCODE V44
  Description: Homo sapiens ATP synthase F1 subunit beta (ATP5F1B), mRNA; nuclear gene for mitochondrial product. (from RefSeq NM_001686)
RefSeq Summary (NM_001686): This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000262030.8
Gencode Gene: ENSG00000110955.9
Transcript (Including UTRs)
   Position: hg38 chr12:56,638,175-56,645,984 Size: 7,810 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr12:56,638,323-56,645,963 Size: 7,641 Coding Exon Count: 10 

Page IndexSequence and LinksPrimersRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:56,638,175-56,645,984)mRNA (may differ from genome)Protein (529 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGencodeGeneCardsHPRD
LynxMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 980.41 RPKM in Heart - Left Ventricle
Total median expression: 12534.17 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.7021-0.176 Picture PostScript Text
3' UTR -25.60148-0.173 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsembl SGD
Protein SequenceProtein SequenceProtein SequenceProtein Sequence Protein Sequence
AlignmentAlignmentAlignmentAlignment Alignment

-  Descriptions from all associated GenBank mRNAs
  BC016512 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide, mRNA (cDNA clone MGC:5231 IMAGE:2900336), complete cds.
FJ224288 - Homo sapiens epididymis secretory protein Li 271 (HEL-S-271) mRNA, complete cds.
AK130793 - Homo sapiens cDNA FLJ27283 fis, clone TMS01431, highly similar to ATP synthase beta chain, mitochondrial precursor (EC 3.6.1.34).
AK291085 - Homo sapiens cDNA FLJ76178 complete cds, highly similar to Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B), mRNA.
D00022 - Homo sapiens mRNA for F1 beta subunit, complete cds.
X03559 - Human mRNA for F1-ATPase beta subunit (F-1 beta).
JD418776 - Sequence 399800 from Patent EP1572962.
X05606 - Human mRNA fragment for ATP synthetase beta-subunit.
KJ890733 - Synthetic construct Homo sapiens clone ccsbBroadEn_00127 ATP5B gene, encodes complete protein.
DQ891585 - Synthetic construct clone IMAGE:100004215; FLH178367.01X; RZPDo839C05128D ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) gene, encodes complete protein; nuclear gene for mitochondrial product.
DQ894779 - Synthetic construct Homo sapiens clone IMAGE:100009239; FLH178364.01L; RZPDo839C05127D ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) gene, encodes complete protein; nuclear gene for mitochondrial product.
AB489161 - Synthetic construct DNA, clone: pF1KB5207, Homo sapiens ATP5B gene for ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide, without stop codon, in Flexi system.
DQ403107 - Homo sapiens mitochondrial ATP synthase, H+ transporting F1 complex beta subunit (ATP5B) mRNA, partial cds; nuclear gene for mitochondrial product.
CU677643 - Synthetic construct Homo sapiens gateway clone IMAGE:100019786 5' read ATP5B mRNA.
JD387758 - Sequence 368782 from Patent EP1572962.
JD423631 - Sequence 404655 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

BioCyc Knowledge Library
PWY-7980 - ATP biosynthesis

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000262030.1, ENST00000262030.2, ENST00000262030.3, ENST00000262030.4, ENST00000262030.5, ENST00000262030.6, ENST00000262030.7, NM_001686, uc001slr.1, uc001slr.2, uc001slr.3, uc001slr.4, uc001slr.5, V9HW31
UCSC ID: ENST00000262030.8
RefSeq Accession: NM_001686
CCDS: CCDS8924.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.