ID:B3GN6_HUMAN DESCRIPTION: RecName: Full=UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6; Short=BGnT-6; Short=Beta-1,3-Gn-T6; Short=Beta-1,3-N-acetylglucosaminyltransferase 6; Short=Beta3Gn-T6; EC=2.4.1.-; AltName: Full=Core 3 synthase; FUNCTION: Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important precursor in the biosynthesis of mucin-type glycoproteins. Plays an important role in the synthesis of mucin-type O-glycans in digestive organs. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein. TISSUE SPECIFICITY: Present in stomach and colon (at protein level). Restricted in the stomach, colon and small intestine, where core 3 structure is present. INDUCTION: Down-regulated in gastric and colorectal carcinomas, suggesting that it may be used as a marker for distinguishing between benign adenomas and premalignant lesions (at protein level). MISCELLANEOUS: Injection into nude mice significantly suppress lung metastasis, indicating that the core structures of O-glycans are profoundly involved in the metastatic capacity of cancer cells. SIMILARITY: Belongs to the glycosyltransferase 31 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=B3GNT6";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZMB0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK292773 - Homo sapiens cDNA FLJ78031 complete cds, highly similar to Homo sapiens beta3GnT6 mRNA for beta-1,3-N-acetylglucosaminyltransferase 6. AK127544 - Homo sapiens cDNA FLJ45637 fis, clone COLON2004351, weakly similar to Probable beta-1,3-galactosyltransferase 8 (EC 2.4.1.-). AK313682 - Homo sapiens cDNA, FLJ94270, Homo sapiens beta-1,3-N-acetylglucosaminyltransferase protein(IMAGE:4907098), mRNA. AK172863 - Homo sapiens cDNA FLJ24093 fis, clone KAIA2504. BC103908 - Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase), mRNA (cDNA clone MGC:119334 IMAGE:40005856), complete cds. BC103909 - Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase), mRNA (cDNA clone MGC:119336 IMAGE:40005863), complete cds. BC103910 - Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase), mRNA (cDNA clone MGC:119337 IMAGE:40005864), complete cds. KJ905639 - Synthetic construct Homo sapiens clone ccsbBroadEn_15280 B3GNT6 gene, encodes complete protein. AB073740 - Homo sapiens beta3GnT6 mRNA for beta-1,3-N-acetylglucosaminyltransferase 6, complete cds. BC025357 - Homo sapiens UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase), mRNA (cDNA clone IMAGE:4907098), partial cds. JD353353 - Sequence 334377 from Patent EP1572962. JD118573 - Sequence 99597 from Patent EP1572962. JD086068 - Sequence 67092 from Patent EP1572962. JD518994 - Sequence 500018 from Patent EP1572962. JD385667 - Sequence 366691 from Patent EP1572962. JD497891 - Sequence 478915 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa00512 - O-Glycan biosynthesis hsa01100 - Metabolic pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6ZMB0 (Reactome details) participates in the following event(s):
R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein R-HSA-913709 O-linked glycosylation of mucins R-HSA-5173105 O-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
Sequence and Links to Tools and Databases 
