Human Gene BNIP2 (ENST00000607373.6) from GENCODE V44
Description: Homo sapiens BCL2 interacting protein 2 (BNIP2), transcript variant 2, mRNA. (from RefSeq NM_004330) RefSeq Summary (NM_004330): This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000607373.6 Gencode Gene: ENSG00000140299.14 Transcript (Including UTRs) Position: hg38 chr15:59,659,146-59,689,320 Size: 30,175 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr15:59,664,069-59,682,457 Size: 18,389 Coding Exon Count: 9
ID:BNIP2_HUMAN DESCRIPTION: RecName: Full=BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; FUNCTION: Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Note=Localizes to the nuclear envelope region and to other cytoplasmic structures. SIMILARITY: Contains 1 CRAL-TRIO domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bnip2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF12496 - Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
ModBase Predicted Comparative 3D Structure on Q12982
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043547 positive regulation of GTPase activity GO:0051149 positive regulation of muscle cell differentiation
US Server
