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Human Gene BPIFA2 (ENST00000354932.6) from GENCODE V50
  Description: BPI fold containing family A member 2, transcript variant 1 (from RefSeq NM_080574.4)
Gencode Transcript: ENST00000354932.6
Gencode Gene: ENSG00000131050.11
Transcript (Including UTRs)
   Position: hg38 chr20:33,168,159-33,181,412 Size: 13,254 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr20:33,169,146-33,180,560 Size: 11,415 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: BPIA2_HUMAN
DESCRIPTION: RecName: Full=BPI fold-containing family A member 2; AltName: Full=Parotid secretory protein; Short=PSP; AltName: Full=Short palate, lung and nasal epithelium carcinoma-associated protein 2; Flags: Precursor;
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Detected in submandibular gland.
SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. Plunc family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: BPIFA2
Diseases sorted by gene-association score: lacrimal apparatus disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.04 RPKM in Testis
Total median expression: 1.70 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.2066-0.215 Picture PostScript Text
3' UTR -59.90226-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017943 - Bactericidal_perm-incr_a/b_dom
IPR017942 - Lipid-bd_serum_glycop_N

Pfam Domains:
PF01273 - LBP / BPI / CETP family, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q96DR5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001530 lipopolysaccharide binding
GO:0005515 protein binding
GO:0008289 lipid binding

Biological Process:
GO:0019730 antimicrobial humoral response
GO:0042742 defense response to bacterium

Cellular Component:
GO:0005576 extracellular region
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AY359055 - Homo sapiens clone DNA59622 C20orf70 (UNQ510) mRNA, complete cds.
AK291854 - Homo sapiens cDNA FLJ77339 complete cds.
BC065726 - Homo sapiens chromosome 20 open reading frame 70, mRNA (cDNA clone MGC:72029 IMAGE:30326122), complete cds.
AK130487 - Homo sapiens cDNA FLJ26977 fis, clone SLV02302, highly similar to Homo sapiens prolactin-induced protein (PIP).
CU688090 - Synthetic construct Homo sapiens gateway clone IMAGE:100023134 5' read C20orf70 mRNA.
HQ447565 - Synthetic construct Homo sapiens clone IMAGE:100070906; CCSB014831_02 chromosome 20 open reading frame 70 (C20orf70) gene, encodes complete protein.
AF432917 - Homo sapiens parotid secretory protein mRNA, complete cds.
AK130550 - Homo sapiens cDNA FLJ27040 fis, clone SLV08542.
AK130543 - Homo sapiens cDNA FLJ27033 fis, clone SLV07833.
JD190582 - Sequence 171606 from Patent EP1572962.
JD352745 - Sequence 333769 from Patent EP1572962.
JD494847 - Sequence 475871 from Patent EP1572962.
JD098719 - Sequence 79743 from Patent EP1572962.
JD375075 - Sequence 356099 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96DR5 (Reactome details) participates in the following event(s):

R-HSA-6809521 BPIF binds bacteria
R-HSA-6803157 Antimicrobial peptides
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: BPIA2_HUMAN, C20orf70, ENST00000354932.1, ENST00000354932.2, ENST00000354932.3, ENST00000354932.4, ENST00000354932.5, NM_080574, Q96DR5, Q9BQQ0, SPLUNC2, uc002wyo.1, uc002wyo.2, uc002wyo.3, UNQ510/PRO1025
UCSC ID: ENST00000354932.6
RefSeq Accession: NM_080574.4
Protein: Q96DR5 (aka BPIA2_HUMAN)
CCDS: CCDS13214.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.