ID:BRAP_HUMAN DESCRIPTION: RecName: Full=BRCA1-associated protein; EC=6.3.2.-; AltName: Full=BRAP2; AltName: Full=Impedes mitogenic signal propagation; Short=IMP; AltName: Full=RING finger protein 52; AltName: Full=Renal carcinoma antigen NY-REN-63; FUNCTION: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1. INTERACTION: P38398:BRCA1; NbExp=3; IntAct=EBI-349900, EBI-349905; P01112:HRAS; NbExp=3; IntAct=EBI-349900, EBI-350145; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed in breast epithelial cell lines. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 UBP-type zinc finger. SEQUENCE CAUTION: Sequence=AAC24200.1; Type=Frameshift; Positions=556;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07576 - BRCA1-associated protein 2 PF13639 - Ring finger domain PF02148 - Zn-finger in ubiquitin-hydrolases and other protein
ModBase Predicted Comparative 3D Structure on Q7Z569
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000165 MAPK cascade GO:0007265 Ras protein signal transduction GO:0009968 negative regulation of signal transduction GO:0016567 protein ubiquitination
Sequence and Links to Tools and Databases 
Microarray Expression Data 
