Human Gene BRS3 (ENST00000370648.4)
  Description: Homo sapiens bombesin receptor subtype 3 (BRS3), mRNA. (from RefSeq NM_001727)
RefSeq Summary (NM_001727): The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011].
Gencode Transcript: ENST00000370648.4
Gencode Gene: ENSG00000102239.5
Transcript (Including UTRs)
   Position: hg38 chrX:136,487,947-136,493,780 Size: 5,834 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chrX:136,488,115-136,492,375 Size: 4,261 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrX:136,487,947-136,493,780)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Bombesin receptor subtype-3; Short=BRS-3;
FUNCTION: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SUBUNIT: Interacts with C6orf89.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: In germ cells in testis. Lung carcinoma cells.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: BRS3
Diseases sorted by gene-association score: lung cancer (3), obesity (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.43 RPKM in Fallopian Tube
Total median expression: 2.28 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.10168-0.191 Picture PostScript Text
3' UTR -326.001405-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001560 - Bombesin_rcpt_3
IPR001556 - Bombsn_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P32247
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004946 bombesin receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0008343 adult feeding behavior
GO:0031989 bombesin receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body

-  Descriptions from all associated GenBank mRNAs
  JD180388 - Sequence 161412 from Patent EP1572962.
L08893 - Human bombesin receptor subtype-3 mRNA, complete cds.
JD526678 - Sequence 507702 from Patent EP1572962.
JD298776 - Sequence 279800 from Patent EP1572962.
JD252851 - Sequence 233875 from Patent EP1572962.
JD120092 - Sequence 101116 from Patent EP1572962.
JD428167 - Sequence 409191 from Patent EP1572962.
JD156694 - Sequence 137718 from Patent EP1572962.
AB528791 - Synthetic construct DNA, clone: pF1KE0257, Homo sapiens BRS3 gene for bombesin-like receptor 3, without stop codon, in Flexi system.
BC152938 - Synthetic construct Homo sapiens clone IMAGE:100016147, MGC:184204 bombesin-like receptor 3 (BRS3) mRNA, encodes complete protein.
AY585193 - Homo sapiens bombesin-like receptor 3 mRNA, complete cds.
JD311103 - Sequence 292127 from Patent EP1572962.
JD202526 - Sequence 183550 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P32247 (Reactome details) participates in the following event(s):

R-HSA-375384 Bombesin-like receptors bind bombesin homologues
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BRS3_HUMAN, ENST00000370648.1, ENST00000370648.2, ENST00000370648.3, NM_001727, P32247, uc004ezv.1, uc004ezv.2, uc004ezv.3
UCSC ID: ENST00000370648.4
RefSeq Accession: NM_001727
Protein: P32247 (aka BRS3_HUMAN)
CCDS: CCDS14656.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.