Description: Homo sapiens bombesin receptor subtype 3 (BRS3), mRNA. (from RefSeq NM_001727) RefSeq Summary (NM_001727): The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]. Gencode Transcript: ENST00000370648.4 Gencode Gene: ENSG00000102239.5 Transcript (Including UTRs) Position: hg38 chrX:136,487,947-136,493,780 Size: 5,834 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chrX:136,488,115-136,492,375 Size: 4,261 Coding Exon Count: 3
ID:BRS3_HUMAN DESCRIPTION: RecName: Full=Bombesin receptor subtype-3; Short=BRS-3; FUNCTION: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. SUBUNIT: Interacts with C6orf89. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: In germ cells in testis. Lung carcinoma cells. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P32247
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.