Human Gene BRS3 (ENST00000370648.4)
  Description: Homo sapiens bombesin receptor subtype 3 (BRS3), mRNA. (from RefSeq NM_001727)
RefSeq Summary (NM_001727): The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011].
Gencode Transcript: ENST00000370648.4
Gencode Gene: ENSG00000102239.5
Transcript (Including UTRs)
   Position: hg38 chrX:136,487,947-136,493,780 Size: 5,834 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg38 chrX:136,488,115-136,492,375 Size: 4,261 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:136,487,947-136,493,780)mRNA (may differ from genome)Protein (399 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: BRS3_HUMAN
DESCRIPTION: RecName: Full=Bombesin receptor subtype-3; Short=BRS-3;
FUNCTION: Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
SUBUNIT: Interacts with C6orf89.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: In germ cells in testis. Lung carcinoma cells.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: BRS3
Diseases sorted by gene-association score: lung cancer (3), obesity (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.43 RPKM in Fallopian Tube
Total median expression: 2.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -32.10168-0.191 Picture PostScript Text
3' UTR -326.001405-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR001560 - Bombesin_rcpt_3
IPR001556 - Bombsn_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on P32247
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004946 bombesin receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0006006 glucose metabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0008343 adult feeding behavior
GO:0031989 bombesin receptor signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body


-  Descriptions from all associated GenBank mRNAs
  JD180388 - Sequence 161412 from Patent EP1572962.
L08893 - Human bombesin receptor subtype-3 mRNA, complete cds.
JD526678 - Sequence 507702 from Patent EP1572962.
JD298776 - Sequence 279800 from Patent EP1572962.
JD252851 - Sequence 233875 from Patent EP1572962.
JD120092 - Sequence 101116 from Patent EP1572962.
JD428167 - Sequence 409191 from Patent EP1572962.
JD156694 - Sequence 137718 from Patent EP1572962.
AB528791 - Synthetic construct DNA, clone: pF1KE0257, Homo sapiens BRS3 gene for bombesin-like receptor 3, without stop codon, in Flexi system.
BC152938 - Synthetic construct Homo sapiens clone IMAGE:100016147, MGC:184204 bombesin-like receptor 3 (BRS3) mRNA, encodes complete protein.
AY585193 - Homo sapiens bombesin-like receptor 3 mRNA, complete cds.
JD311103 - Sequence 292127 from Patent EP1572962.
JD202526 - Sequence 183550 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction

Reactome (by CSHL, EBI, and GO)

Protein P32247 (Reactome details) participates in the following event(s):

R-HSA-375384 Bombesin-like receptors bind bombesin homologues
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: BRS3_HUMAN, ENST00000370648.1, ENST00000370648.2, ENST00000370648.3, NM_001727, P32247, uc004ezv.1, uc004ezv.2, uc004ezv.3
UCSC ID: ENST00000370648.4
RefSeq Accession: NM_001727
Protein: P32247 (aka BRS3_HUMAN)
CCDS: CCDS14656.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.