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Human Gene BTN2A2 (ENST00000356709.9) from GENCODE V50
  Description: butyrophilin subfamily 2 member A2, transcript variant 1 (from RefSeq NM_006995.5)
Gencode Transcript: ENST00000356709.9
Gencode Gene: ENSG00000124508.19
Transcript (Including UTRs)
   Position: hg38 chr6:26,383,108-26,394,874 Size: 11,767 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr6:26,383,822-26,392,967 Size: 9,146 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: BT2A2_HUMAN
DESCRIPTION: RecName: Full=Butyrophilin subfamily 2 member A2; Flags: Precursor;
FUNCTION: Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.
PTM: N-glycosylated (By similarity).
SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
SIMILARITY: Contains 1 B30.2/SPRY domain.
SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.42 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 139.60 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -31.20104-0.300 Picture PostScript Text
3' UTR -551.901907-0.289 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001870 - B30.2/SPRY
IPR003879 - Butyrophylin
IPR013162 - CD80_C2-set
IPR008985 - ConA-like_lec_gl_sf
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013106 - Ig_V-set
IPR006574 - PRY
IPR018355 - SPla/RYanodine_receptor_subgr
IPR003877 - SPRY_rcpt

Pfam Domains:
PF08205 - CD80-like C2-set immunoglobulin domain
PF00622 - SPRY domain
PF07686 - Immunoglobulin V-set domain

ModBase Predicted Comparative 3D Structure on Q8WVV5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0031324 negative regulation of cellular metabolic process
GO:0046007 negative regulation of activated T cell proliferation
GO:0050710 negative regulation of cytokine secretion

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK304744 - Homo sapiens cDNA FLJ52852 complete cds, highly similar to Homo sapiens butyrophilin, subfamily 2, member A2 (BTN2A2), transcript variant 2, mRNA.
AK289883 - Homo sapiens cDNA FLJ75106 complete cds, highly similar to Homo sapiens butyrophilin, subfamily 2, member A2 (BTN2A2), transcript variant 2, mRNA.
AK293526 - Homo sapiens cDNA FLJ52475 complete cds, highly similar to Butyrophilin subfamily 2 member A2 precursor.
AK298570 - Homo sapiens cDNA FLJ52717 complete cds, highly similar to Butyrophilin subfamily 2 member A2 precursor.
U90550 - Human butyrophilin (BTF2) mRNA, complete cds.
BC017497 - Homo sapiens butyrophilin, subfamily 2, member A2, mRNA (cDNA clone MGC:20007 IMAGE:4648935), complete cds.
BC014021 - Homo sapiens butyrophilin, subfamily 2, member A2, mRNA (cDNA clone MGC:20294 IMAGE:4124138), complete cds.
JD472038 - Sequence 453062 from Patent EP1572962.
BC013258 - Homo sapiens butyrophilin, subfamily 2, member A2, mRNA (cDNA clone IMAGE:3867325).
CU675996 - Synthetic construct Homo sapiens gateway clone IMAGE:100017041 5' read BTN2A2 mRNA.
KJ901060 - Synthetic construct Homo sapiens clone ccsbBroadEn_10454 BTN2A2 gene, encodes complete protein.
KJ906039 - Synthetic construct Homo sapiens clone ccsbBroadEn_15709 BTN2A2 gene, encodes complete protein.
AK123902 - Homo sapiens cDNA FLJ41908 fis, clone PEBLM2007447, highly similar to Human butyrophilin (BTF1) mRNA.
JD113099 - Sequence 94123 from Patent EP1572962.
JD356859 - Sequence 337883 from Patent EP1572962.
JD222620 - Sequence 203644 from Patent EP1572962.
JD423894 - Sequence 404918 from Patent EP1572962.
JD255406 - Sequence 236430 from Patent EP1572962.
JD236816 - Sequence 217840 from Patent EP1572962.
JD371862 - Sequence 352886 from Patent EP1572962.
JD299760 - Sequence 280784 from Patent EP1572962.
JD512571 - Sequence 493595 from Patent EP1572962.
JD392213 - Sequence 373237 from Patent EP1572962.
JD270705 - Sequence 251729 from Patent EP1572962.
JD122425 - Sequence 103449 from Patent EP1572962.
JD109861 - Sequence 90885 from Patent EP1572962.
JD311452 - Sequence 292476 from Patent EP1572962.
JD237067 - Sequence 218091 from Patent EP1572962.
JD171822 - Sequence 152846 from Patent EP1572962.
JD380041 - Sequence 361065 from Patent EP1572962.
JD373828 - Sequence 354852 from Patent EP1572962.
JD319855 - Sequence 300879 from Patent EP1572962.
JD047391 - Sequence 28415 from Patent EP1572962.
JD115085 - Sequence 96109 from Patent EP1572962.
JD053966 - Sequence 34990 from Patent EP1572962.
JD205092 - Sequence 186116 from Patent EP1572962.
JD064348 - Sequence 45372 from Patent EP1572962.
JD177790 - Sequence 158814 from Patent EP1572962.
JD539157 - Sequence 520181 from Patent EP1572962.
JD442393 - Sequence 423417 from Patent EP1572962.
JD268040 - Sequence 249064 from Patent EP1572962.
JD449852 - Sequence 430876 from Patent EP1572962.
JD463971 - Sequence 444995 from Patent EP1572962.
JD250623 - Sequence 231647 from Patent EP1572962.
JD388530 - Sequence 369554 from Patent EP1572962.
JD061731 - Sequence 42755 from Patent EP1572962.
JD224748 - Sequence 205772 from Patent EP1572962.
JD356082 - Sequence 337106 from Patent EP1572962.
JD063800 - Sequence 44824 from Patent EP1572962.
JD236654 - Sequence 217678 from Patent EP1572962.
JD042266 - Sequence 23290 from Patent EP1572962.
JD251820 - Sequence 232844 from Patent EP1572962.
JD073461 - Sequence 54485 from Patent EP1572962.
JD049949 - Sequence 30973 from Patent EP1572962.
JD378354 - Sequence 359378 from Patent EP1572962.
JD228759 - Sequence 209783 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WVV5 (Reactome details) participates in the following event(s):

R-HSA-8851988 BTN2A2 binds T cell surface
R-HSA-8851680 Butyrophilin (BTN) family interactions
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A6NM84, B4DE97, B4DQ01, BT2.2, BT2A2_HUMAN, BTF2, E9PH07, ENST00000356709.1, ENST00000356709.2, ENST00000356709.3, ENST00000356709.4, ENST00000356709.5, ENST00000356709.6, ENST00000356709.7, ENST00000356709.8, NM_006995, O00480, Q8WVV5, uc003nhq.1, uc003nhq.2, uc003nhq.3, uc003nhq.4, uc003nhq.5
UCSC ID: ENST00000356709.9
RefSeq Accession: NM_006995.5
Protein: Q8WVV5 (aka BT2A2_HUMAN)
CCDS: CCDS4606.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.