Human Gene BTNL2 (ENST00000454136.8) from GENCODE V44
Description: Homo sapiens butyrophilin like 2 (BTNL2), mRNA. (from RefSeq NM_001304561) RefSeq Summary (NM_001304561): This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The exon combination of this transcript is inferred based on partial and orthologous transcript alignments, RNA-seq data, and data in PMID:17237401. Gencode Transcript: ENST00000454136.8 Gencode Gene: ENSG00000204290.11 Transcript (Including UTRs) Position: hg38 chr6:32,393,339-32,407,181 Size: 13,843 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr6:32,393,969-32,407,123 Size: 13,155 Coding Exon Count: 7
ID:F8WBA1_HUMAN DESCRIPTION: SubName: Full=Butyrophilin-like protein 2; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on F8WBA1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0042102 positive regulation of T cell proliferation GO:0050860 negative regulation of T cell receptor signaling pathway GO:1900042 positive regulation of interleukin-2 secretion
Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane
Descriptions from all associated GenBank mRNAs
BC119668 - Homo sapiens butyrophilin-like 2 (MHC class II associated), mRNA (cDNA clone IMAGE:40116163), complete cds. BC127641 - Homo sapiens butyrophilin-like 2 (MHC class II associated), mRNA (cDNA clone IMAGE:40116161), complete cds. BC127642 - Homo sapiens butyrophilin-like 2 (MHC class II associated), mRNA (cDNA clone MGC:157676 IMAGE:40116164), complete cds. KJ902904 - Synthetic construct Homo sapiens clone ccsbBroadEn_12298 BTNL2 gene, encodes complete protein. AY684332 - Homo sapiens BTNL2_E mRNA, partial cds. AY684333 - Homo sapiens BTNL2_I mRNA, partial cds.
US Server
