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Human Gene HIKESHI (ENST00000278483.8) from GENCODE V50
  Description: heat shock protein nuclear import factor hikeshi, transcript variant 1 (from RefSeq NM_016401.4)
Gencode Transcript: ENST00000278483.8
Gencode Gene: ENSG00000149196.19
Transcript (Including UTRs)
   Position: hg38 chr11:86,302,240-86,345,943 Size: 43,704 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr11:86,302,449-86,345,638 Size: 43,190 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2026-07-12 09:30:09

-  Comments and Description Text from UniProtKB
  ID: HIKES_HUMAN
DESCRIPTION: RecName: Full=Protein Hikeshi;
FUNCTION: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
SUBUNIT: Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats).
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus.
INDUCTION: Following heat-shock treatment.
MISCELLANEOUS: 'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter (PubMed:22541429).
SIMILARITY: Belongs to the OPI10 family.
SEQUENCE CAUTION: Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Sequence=AAF29142.1; Type=Frameshift; Positions=9, 57; Sequence=AAF36168.1; Type=Frameshift; Positions=67;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HIKESHI
Diseases sorted by gene-association score: leukodystrophy, hypomyelinating, 13* (829), hypomyelinating leukoencephalopathy (25)
* = Manually curated disease association

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.86 RPKM in Ovary
Total median expression: 573.71 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.30209-0.432 Picture PostScript Text
3' UTR -46.80305-0.153 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008493 - DUF775

Pfam Domains:
PF05603 - Protein of unknown function (DUF775)

ModBase Predicted Comparative 3D Structure on Q53FT3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsembl SGD
Protein SequenceProtein SequenceProtein SequenceProtein Sequence Protein Sequence
AlignmentAlignmentAlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008565 protein transporter activity
GO:0030544 Hsp70 protein binding

Biological Process:
GO:0006606 protein import into nucleus
GO:0007030 Golgi organization
GO:0015031 protein transport
GO:0030324 lung development
GO:0034605 cellular response to heat
GO:1900034 regulation of cellular response to heat

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AF161527 - Homo sapiens HSPC179 mRNA, complete cds.
AF161487 - Homo sapiens HSPC138 mRNA, complete cds.
AK001447 - Homo sapiens cDNA FLJ10585 fis, clone NT2RP2003793.
AK223198 - Homo sapiens mRNA for hypothetical protein HSPC138 variant, clone: REC01582.
BC015991 - Homo sapiens chromosome 11 open reading frame 73, mRNA (cDNA clone MGC:2697 IMAGE:2820691), complete cds.
BC021621 - Homo sapiens chromosome 11 open reading frame 73, mRNA (cDNA clone MGC:4325 IMAGE:2820691), complete cds.
AK298763 - Homo sapiens cDNA FLJ57139 complete cds.
BC018080 - Homo sapiens chromosome 11 open reading frame 73, mRNA (cDNA clone MGC:26811 IMAGE:4798958), complete cds.
BC001677 - Homo sapiens chromosome 11 open reading frame 73, mRNA (cDNA clone MGC:2700 IMAGE:2820772), complete cds.
BC006476 - Homo sapiens chromosome 11 open reading frame 73, mRNA (cDNA clone MGC:4328 IMAGE:2820772), complete cds.
JD080284 - Sequence 61308 from Patent EP1572962.
JD123809 - Sequence 104833 from Patent EP1572962.
DQ895977 - Synthetic construct Homo sapiens clone IMAGE:100010437; FLH189181.01L; RZPDo839C0664D chromosome 11 open reading frame 73 (C11orf73) gene, encodes complete protein.
DQ892731 - Synthetic construct clone IMAGE:100005361; FLH189185.01X; RZPDo839C0674D chromosome 11 open reading frame 73 (C11orf73) gene, encodes complete protein.
CU674828 - Synthetic construct Homo sapiens gateway clone IMAGE:100018013 5' read C11orf73 mRNA.
CU676162 - Synthetic construct Homo sapiens gateway clone IMAGE:100020237 5' read C11orf73 mRNA.
KJ893923 - Synthetic construct Homo sapiens clone ccsbBroadEn_03317 C11orf73 gene, encodes complete protein.
KJ898906 - Synthetic construct Homo sapiens clone ccsbBroadEn_08300 C11orf73 gene, encodes complete protein.
AF151082 - Homo sapiens HSPC248 mRNA, complete cds.
AK125010 - Homo sapiens cDNA FLJ43020 fis, clone BRTHA2018504.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q53FT3 (Reactome details) participates in the following event(s):

R-HSA-5251942 Hikeshi binds HSP70s:ATP
R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-3371556 Cellular response to heat stress
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: C11orf73, ENST00000278483.1, ENST00000278483.2, ENST00000278483.3, ENST00000278483.4, ENST00000278483.5, ENST00000278483.6, ENST00000278483.7, HIKESHI , HIKES_HUMAN, HSPC138, HSPC179, HSPC248, NM_016401, Q53FT3, Q8WVE8, Q9NVQ2, Q9NZZ1, Q9P022, Q9P0N1, uc001pbu.1, uc001pbu.2, uc001pbu.3, uc001pbu.4, uc001pbu.5
UCSC ID: ENST00000278483.8
RefSeq Accession: NM_016401.4
Protein: Q53FT3 (aka HIKES_HUMAN)
CCDS: CCDS8275.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.