Human Gene C3AR1 (ENST00000307637.5) Description and Page Index
  Description: Homo sapiens complement C3a receptor 1 (C3AR1), transcript variant 1, mRNA. (from RefSeq NM_004054)
RefSeq Summary (NM_004054): C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016].
Gencode Transcript: ENST00000307637.5
Gencode Gene: ENSG00000171860.5
Transcript (Including UTRs)
   Position: hg38 chr12:8,056,844-8,066,359 Size: 9,516 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr12:8,058,737-8,060,185 Size: 1,449 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:8,056,844-8,066,359)mRNA (may differ from genome)Protein (482 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: C3AR_HUMAN
DESCRIPTION: RecName: Full=C3a anaphylatoxin chemotactic receptor; Short=C3AR; Short=C3a-R;
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/c3ar1/";

-  MalaCards Disease Associations
  MalaCards Gene Search: C3AR1
Diseases sorted by gene-association score: c3 deficiency (16), occupational dermatitis (15)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.34 RPKM in Whole Blood
Total median expression: 217.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -25.0092-0.272 Picture PostScript Text
3' UTR -425.301893-0.225 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR002234 - Anphylx_rcpt
IPR001644 - C3A_anaphtx_rcpt
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

ModBase Predicted Comparative 3D Structure on Q16581
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004875 complement receptor activity
GO:0004876 complement component C3a receptor activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0002430 complement receptor mediated signaling pathway
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008015 blood circulation
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0030449 regulation of complement activation
GO:0043312 neutrophil degranulation
GO:0045766 positive regulation of angiogenesis
GO:0050900 leukocyte migration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326 cell chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0035577 azurophil granule membrane
GO:0035579 specific granule membrane


-  Descriptions from all associated GenBank mRNAs
  DQ892004 - Synthetic construct clone IMAGE:100004634; FLH182231.01X; RZPDo839E01138D complement component 3a receptor 1 (C3AR1) gene, encodes complete protein.
DQ895197 - Synthetic construct Homo sapiens clone IMAGE:100009657; FLH263712.01L; RZPDo839E05137D complement component 3a receptor 1 (C3AR1) gene, encodes complete protein.
DQ896840 - Synthetic construct Homo sapiens clone IMAGE:100011300; FLH182227.01L; RZPDo839E01137D complement component 3a receptor 1 (C3AR1) gene, encodes complete protein.
LF207382 - JP 2014500723-A/14885: Polycomb-Associated Non-Coding RNAs.
MA442959 - JP 2018138019-A/14885: Polycomb-Associated Non-Coding RNAs.
U28488 - Human putative G protein-coupled receptor (AZ3B) mRNA, complete cds.
U62027 - Human anaphylatoxin C3a receptor (HNFAG09) mRNA, complete cds.
BC020742 - Homo sapiens complement component 3a receptor 1, mRNA (cDNA clone MGC:22570 IMAGE:4690283), complete cds.
JD510313 - Sequence 491337 from Patent EP1572962.
JD221095 - Sequence 202119 from Patent EP1572962.
AK290242 - Homo sapiens cDNA FLJ78205 complete cds, highly similar to Homo sapiens complement component 3a receptor 1, mRNA.
JD048206 - Sequence 29230 from Patent EP1572962.
JD544460 - Sequence 525484 from Patent EP1572962.
AK223388 - Homo sapiens mRNA for complement component 3a receptor 1 variant, clone: FCC106H01.
JD178712 - Sequence 159736 from Patent EP1572962.
JD102317 - Sequence 83341 from Patent EP1572962.
Z73157 - H.sapiens mRNA for C3a anaphylatoxin receptor.
AK312458 - Homo sapiens cDNA, FLJ92813, Homo sapiens complement component 3a receptor 1 (C3AR1), mRNA.
KJ890791 - Synthetic construct Homo sapiens clone ccsbBroadEn_00185 C3AR1 gene, encodes complete protein.
AB463537 - Synthetic construct DNA, clone: pF1KB7171, Homo sapiens C3AR1 gene for complement component 3a receptor 1, without stop codon, in Flexi system.
LF365770 - JP 2014500723-A/173273: Polycomb-Associated Non-Coding RNAs.
MA601347 - JP 2018138019-A/173273: Polycomb-Associated Non-Coding RNAs.
LF365771 - JP 2014500723-A/173274: Polycomb-Associated Non-Coding RNAs.
MA601348 - JP 2018138019-A/173274: Polycomb-Associated Non-Coding RNAs.
CU676680 - Synthetic construct Homo sapiens gateway clone IMAGE:100022286 5' read C3AR1 mRNA.
JD081692 - Sequence 62716 from Patent EP1572962.
JD282848 - Sequence 263872 from Patent EP1572962.
JD061225 - Sequence 42249 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04080 - Neuroactive ligand-receptor interaction
hsa04610 - Complement and coagulation cascades

Reactome (by CSHL, EBI, and GO)

Protein Q16581 (Reactome details) participates in the following event(s):

R-HSA-444647 C3a receptor binds anaphylatoxin C3a
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-6798739 Exocytosis of azurophil granule membrane proteins
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-977606 Regulation of Complement cascade
R-HSA-418594 G alpha (i) signalling events
R-HSA-6798695 Neutrophil degranulation
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-166658 Complement cascade
R-HSA-388396 GPCR downstream signalling
R-HSA-168249 Innate Immune System
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: AZ3B, C3AR_HUMAN, C3R1, HNFAG09, NM_004054, O43771, Q16581, Q92868, uc001qtv.1, uc001qtv.2, uc001qtv.3
UCSC ID: uc001qtv.3
RefSeq Accession: NM_004054
Protein: Q16581 (aka C3AR_HUMAN)
CCDS: CCDS8588.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.