Human Gene C4A (ENST00000375295.8) from GENCODE V44
Description: Homo sapiens complement C4A (Rodgers blood group) (C4A), transcript variant 1, mRNA. (from RefSeq NM_007293) RefSeq Summary (NM_001002029): This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, May 2020]. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000435363.7/ ENSP00000415941.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000375295.8 Gencode Gene: ENSG00000244207.8 Transcript (Including UTRs) Position: hg38 chr6_GL000252v2_alt:3,229,797-3,250,455 Size: 20,659 Total Exon Count: 41 Strand: + Coding Region Position: hg38 chr6_GL000252v2_alt:3,229,881-3,250,314 Size: 20,434 Coding Exon Count: 41
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
