Human Gene CAMK1D (ENST00000619168.4) Description and Page Index
Description: Homo sapiens calcium/calmodulin dependent protein kinase ID (CAMK1D), transcript variant 2, mRNA. (from RefSeq NM_153498) RefSeq Summary (NM_153498): This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000619168.4 Gencode Gene: ENSG00000183049.12 Transcript (Including UTRs) Position: hg38 chr10:12,349,482-12,835,545 Size: 486,064 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr10:12,349,819-12,828,887 Size: 479,069 Coding Exon Count: 11
ID:KCC1D_HUMAN DESCRIPTION: RecName: Full=Calcium/calmodulin-dependent protein kinase type 1D; EC=2.7.11.17; AltName: Full=CaM kinase I delta; Short=CaM kinase ID; Short=CaM-KI delta; Short=CaMKI delta; Short=CaMKID; AltName: Full=CaMKI-like protein kinase; Short=CKLiK; FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-180 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-180 results in several fold increase in total activity. Unlike CaMK4, may be unable to exhibit autonomous activity after Ca(2+)/calmodulin activation. SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus (Probable). Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons. TISSUE SPECIFICITY: Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. DEVELOPMENTAL STAGE: Expressed during hippocampal formation with high expression in the pyramidal cell layers. INDUCTION: Expression increases upon treatment of EC cells with DMSO and retinoic acid. Induced by KCL in PC12 cells. DOMAIN: The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IU85
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0006954 inflammatory response GO:0007399 nervous system development GO:0008152 metabolic process GO:0010976 positive regulation of neuron projection development GO:0016310 phosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0032793 positive regulation of CREB transcription factor activity GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0050766 positive regulation of phagocytosis GO:0050773 regulation of dendrite development GO:0060267 positive regulation of respiratory burst GO:0071622 regulation of granulocyte chemotaxis GO:0090023 positive regulation of neutrophil chemotaxis
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